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Rephrasing anaphase: separase FEARs shugoshin

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Abstract

Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic model has recently been extended by exciting discoveries on three levels: regulation of anaphase by posttranslational modifications and the cohesin protector shugoshin; non-proteolytic roles of separase; and cohesin-independent linkage of sister chromatids.

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Acknowledgements

We apologize to our colleagues whose work could not be cited due to space constraints. O.S. is supported by grants from the Deutsche Forschungsgemeinschaft (DFG; Emmy Noether Program) and from the Human Frontier Science Program.

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  1. Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany

    Olaf Stemmann, Dominik Boos & Ingo H. Gorr

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  1. Olaf Stemmann
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Correspondence to Olaf Stemmann.

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Communicated by F. Uhlmann

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Stemmann, O., Boos, D. & Gorr, I.H. Rephrasing anaphase: separase FEARs shugoshin. Chromosoma 113, 409–417 (2005). https://doi.org/10.1007/s00412-005-0331-y

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