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Early Detection of Bi-ventricular and Atrial Mechanical Dysfunction Using Two-Dimensional Speckle Tracking Echocardiography in Patients with Sarcoidosis

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Abstract

Purpose

Sarcoidosis is a systemic inflammatory disease with unknown etiology involving several organs. Myocardial involvement, pericarditis, severe rhythm abnormalities, and heart valve disease due to papillary muscle dysfunction are some of the cardiac manifestations. Conventional echocardiographic methods remain insufficient for the determination of subclinical myocardial dysfunction in patients with sarcoidosis. In our study, we investigated the impact of sarcoidosis on bi-ventricular and atrial functions using two-dimensional (2D) speckle tracking echocardiography (STE).

Methods

Forty patients with sarcoidosis and 20 age and sex-matched controls were recruited into study. All subjects underwent a transthoracic echocardiography for the evaluation of ventricular and atrial functions with 2D STE.

Results

Left ventricular (LV) dimensions, LV ejection fraction, and right ventricular (RV) systolic velocity were similar between the two groups. Left atrial (LA) diameter was significantly higher in sarcoidosis patients than controls. Eighteen (45 %) patients in the sarcoidosis group and 1 (5 %) patient in the control group had LV diastolic dysfunction. LV global longitudinal, radial, circumferential strain, twist, untwists, and RV global longitudinal strain values were significantly lower in sarcoidosis patients compared to controls. LA and RA reservoir functions were also significantly lower in sarcoidosis patients than controls.

Conclusion

Although impaired LV diastolic function was detected using conventional parameters, only novel advanced echocardiographic modalities demonstrated impaired bi-ventricular and atrial mechanical functions in patients with sarcoidosis.

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Conflict of interest

None to declare.

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Authors and Affiliations

  1. Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey

    Kursat Tigen & Murat Sunbul

  2. Department of Cardiology, Acibadem University Faculty of Medicine, Istanbul, Turkey

    Tansu Karaahmet

  3. Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey

    Onur Tasar & Cihan Dundar

  4. Pulmonary Medicine Clinic, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey

    Murat Yalcinsoy & Esen Akkaya

  5. Department of Endocrinology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey

    Mumtaz Takir

  6. Marmara University Education and Research Hospital, Fevzi Cakmak Mahallesi, Muhsin Yazicioglu Caddesi, No: 10, Pendik, Istanbul, Turkey

    Murat Sunbul

Authors
  1. Kursat Tigen
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  2. Murat Sunbul
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  3. Tansu Karaahmet
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  4. Onur Tasar
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  5. Cihan Dundar
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  6. Murat Yalcinsoy
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  7. Mumtaz Takir
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  8. Esen Akkaya
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Corresponding author

Correspondence to Murat Sunbul.

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Tigen, K., Sunbul, M., Karaahmet, T. et al. Early Detection of Bi-ventricular and Atrial Mechanical Dysfunction Using Two-Dimensional Speckle Tracking Echocardiography in Patients with Sarcoidosis. Lung 193, 669–675 (2015). https://doi.org/10.1007/s00408-015-9748-0

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  • DOI: https://doi.org/10.1007/s00408-015-9748-0

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