ORIGINAL PAPER

European Archives of Psychiatry and Clinical Neuroscience

, Volume 258, Issue 3, pp 179-185

Mismatch negativity at acute and post-acute phases of first-episode schizophrenia

  • Müge Devrim-ÜçokAffiliated withDepartment of Physiology, Istanbul Medical Faculty, University of Istanbul Email author 
  • , H. Yasemin Keskin-ErgenAffiliated withDepartment of Physiology, Istanbul Medical Faculty, University of Istanbul
  • , Alp ÜçokAffiliated withDepartment of Psychiatry, Istanbul Medical Faculty, University of Istanbul

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Abstract

The objective of this study was to evaluate the mismatch negativity (MMN) in patients with first-episode schizophrenia at acute and post-acute phases in order to determine the contribution of trait and/or state features to MMN disturbances in schizophrenia. Subject groups comprised 30 patients with first-episode schizophrenia at the acute phase and 34 healthy controls. Ten patients were neuroleptic-naive during testing at the acute phase. Twenty-one patients were retested at the post-acute phase when their symptoms improved. All patients were taking antipsychotic medication at the post-acute retest session. MMN amplitude of the patients at acute phase did not differ from controls. However, MMN amplitude at post-acute phase was reduced compared to both controls and acute phase. Similar results were obtained when the analyses were confined to neuroleptic-naive patients. The sensory memory functions indexed by MMN seem to be unaffected at the onset of schizophrenia but deteriorated during the post-acute illness phase. MMN reduction at the post-acute phase might be emerged from antipsychotic medication.

Key words

schizophrenia first-episode mismatch negativity acute phase post-acute phase longitudinal