Laryngology

European Archives of Oto-Rhino-Laryngology

, Volume 257, Issue 8, pp 445-448

Sarcomatoid carcinoma of the pyriform sinus with brain and subcutaneous metastases: an unusual metastatic spread pattern

  • D. HardissonAffiliated withDepartamento de Anatomía Patológica, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain Fax: +34-917277049 e-mail: dhardiss@idecnet.com
  • , Juan Ignacio De DiegoAffiliated withDepartment of Otorhinolaryngology, La Paz University Hospital, Autonomous University, Madrid, Spain
  • , María Pilar PrimAffiliated withDepartment of Otorhinolaryngology, La Paz University Hospital, Autonomous University, Madrid, Spain

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Abstract

A 63-year-old man presented a polypoid tumor in the laryngeal space involving the right pyriform fossa. The patient underwent a total laryngectomy with bilateral functional neck dissection, and the diagnosis of sarcomatoid carcinoma with malignant fibrous histiocytoma-like stroma was established. The tumor showed an uncommon behavior, with distant metastases to the brain and to the subcutaneous tissue of the abdominal wall. The patient died 1 year after the development of the metastases. Despite its polypoid pattern of growth, sarcomatoid carcinoma of the larynx may behave very aggressively. It is important for clinicians to be aware of the possibility of distant subcutaneous and brain metastases in sarcomatoid tumors of the laryngeal space. If such metastases develop, the prognosis is ominous, with an average life expectancy of 3 months.

Key words Larynx Hypopharynx Metastases Sarcomatoid carcinoma Spindle cell carcinoma