Skip to main content

Advertisement

SpringerLink
Log in

Investigation of the prognostic role of neutrophil-to-lymphocyte ratio in Idiopathic Sudden Sensorineural Hearing Loss based on propensity score matching: a retrospective observational study

  • Miscellaneous
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Introduction

The aetiology, management and prognosis of idiopathic Sdden Sensorineural Hearing Loss (ISSNHL) are still uncertain despite adequate investigation.

Objective

We conducted the present study to investigate the possible relationship between the neutrophil-to-lymphocyte ratio (NLR) and the prognosis of ISSNHL based on PSM.

Methods

This was a retrospective observational study. Data and statistical analyses were performed using the SPSS statistical program (SPSS 19.0). PSM was performed using STATA (15.0).

Results

NLR = 3.42 was the cut-off value. After PSM, 84 pairs of patients were successfully matched. The number of patients in the effective group with the NLR < 3.42 and NLR < 3.42 were significantly different (P < 0.001).

Conclusion

The NLR is an inexpensive and reliable index to predict the ISSNHL. We hold the view that the NLR can be a reliable factor for clinical doctors to predict the prognosis in ISSNHL. To further prove that the NLR is a powerful prognostic factor in ISSNHL, larger prospective studies are required in the future.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Stachler RJ et al (2012) Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg 146:S1–35

    PubMed  Google Scholar 

  2. Chandrasekhar SS et al (2019) Clinical practice guideline: sudden hearing loss (update) executive summary. Otolaryngol Head Neck Surg 161:195–210

    PubMed  Google Scholar 

  3. Mosnier I et al (2011) Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neuro-otol 16:55–66

    Google Scholar 

  4. Lin RJ, Krall R, Westerberg BD, Chadha NK, Chau JK (2012) Systematic review and meta-analysis of the risk factors for sudden sensorineural hearing loss in adults. Laryngoscope 122:624–635

    PubMed  Google Scholar 

  5. Bogaz EA, Maranhao AS, Inoue DP, Suzuki FA, Penido Nde O (2015) Variables with prognostic value in the onset of idiopathic sudden sensorineural hearing loss. Braz J Otorhinolaryngol 81:520–526

    PubMed  Google Scholar 

  6. Psillas G, Rizou A, Rachovitsas D, Tsiropoulos G, Constantinidis J (2019) Hearing outcome of low-tone compared to high-tone sudden sensorineural hearing loss. Int Arch Otorhinolaryngol 23:65–69

    PubMed  Google Scholar 

  7. Attanasio G et al (2018) Prediction of hearing recovery in sudden deafness treated with intratympanic steroids. Acta Otorhinolaryngol Italica 38:453–459

    CAS  Google Scholar 

  8. Lee NH, Ban JH (2010) Is BPPV a prognostic factor in idiopathic sudden sensory hearing loss? Clin Exp Otorhinolaryngol 3:199

    PubMed  PubMed Central  Google Scholar 

  9. Kuhn M, Heman-Ackah SE, Shaikh JA, Roehm PC (2011) Sudden sensorineural hearing loss: a review of diagnosis, treatment, and prognosis. Trends Amplif 15:91–105

    PubMed  PubMed Central  Google Scholar 

  10. Xie S et al (2018) Multivariate analysis of prognostic factors for idiopathic sudden sensorineural hearing loss treated with adjuvant hyperbaric oxygen therapy. Eur Arch Otorhinolaryngol 275:47–51

    PubMed  Google Scholar 

  11. Cao Z et al (2018) Prognostic role of haematological indices in sudden sensorineural hearing loss: review and meta-analysis. Clin Chim Acta 483:104–111

    CAS  PubMed  Google Scholar 

  12. Ohinata Y et al (1994) Blood viscosity and plasma viscosity in patients with sudden deafness. Acta Otolaryngol 114:601–607

    CAS  PubMed  Google Scholar 

  13. Bulgurcu S, Dikilitas B, Arslan IB, Cukurova I (2017) Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in pediatric patients with idiopathic sudden hearing loss. J Int Adv Otol 13:217–220

    PubMed  Google Scholar 

  14. Nonoyama H et al (2016) Red blood cell distribution width predicts prognosis in idiopathic sudden sensorineural hearing loss. Acta Otolaryngol 136:1137–1140

    CAS  PubMed  Google Scholar 

  15. Siegel LG (1975) The treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol Clin North Am 8:467–473

    CAS  PubMed  Google Scholar 

  16. Seo YJ, Jeong JH, Choi JY, Moon IS (2014) Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers 2014:702807

    PubMed  PubMed Central  Google Scholar 

  17. Mattox DE, Simmons FB (1977) Natural history of sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol 86:463–480

    CAS  PubMed  Google Scholar 

  18. Chen XH et al (2019) The natural history of labyrinthine hemorrhage in patients with sudden sensorineural hearing loss. Ear Nose Throat J 98:E13–E20

    PubMed  Google Scholar 

  19. Fetterman BL, Saunders JE, Luxford WM (1996) Prognosis and treatment of sudden sensorineural hearing loss. Am J otol 17:529–536

    CAS  PubMed  Google Scholar 

  20. Chen CY, Halpin C, Rauch SD (2003) Oral steroid treatment of sudden sensorineural hearing loss: a ten year retrospective analysis. Otol neurotol 24:728–733

    PubMed  Google Scholar 

  21. Lawrence R, Thevasagayam R (2015) Controversies in the management of sudden sensorineural hearing loss: an evidence-based review. Clin Otolaryngol 40:176–182

    CAS  PubMed  Google Scholar 

  22. Haynes DS, O'Malley M, Cohen S, Watford K, Labadie RF (2007) Intratympanic dexamethasone for sudden sensorineural hearing loss after failure of systemic therapy. Laryngoscope 117:3–15

    CAS  PubMed  Google Scholar 

  23. Kitoh R et al (2017) Nationwide epidemiological survey of idiopathic sudden sensorineural hearing loss in Japan. Acta Otolaryngol 137:S8–S16

    PubMed  Google Scholar 

  24. Umesawa M et al (2017) Relationships among drinking and smoking habits, history of diseases, body mass index and idiopathic sudden sensorineural hearing loss in Japanese patients. Acta Otolaryngol 137:S17–S23

    PubMed  Google Scholar 

  25. Balde AI et al (2017) Safety analysis of laparoscopic endoscopic cooperative surgery versus endoscopic submucosal dissection for selected gastric gastrointestinal stromal tumors: a propensity score-matched study. Surg Endosc 31:843–851

    CAS  PubMed  Google Scholar 

  26. Balde AI et al (2017) Propensity score analysis of recurrence for neutrophil-to-lymphocyte ratio in colorectal cancer. J Surg Res 219:244–252

    PubMed  Google Scholar 

  27. Brookhart MA et al (2006) Variable selection for propensity score models. Am J Epidemiol 163:1149–1156

    PubMed  PubMed Central  Google Scholar 

  28. Wyss R, Girman CJ, LoCasale RJ, Brookhart AM, Sturmer T (2013) Variable selection for propensity score models when estimating treatment effects on multiple outcomes: a simulation study. Pharmacoepidemiol Drug Saf 22:77–85

    PubMed  Google Scholar 

  29. Merchant SN, Durand ML, Adams JC (2008) Sudden deafness: is it viral? ORL 70:52–60 (discussion 60–52)

    PubMed  Google Scholar 

  30. Garcia-Berrocal JR et al (2005) Immunologic work-up study for inner ear disorders: looking for a rational strategy. Acta Otolaryngol 125:814–818

    PubMed  Google Scholar 

  31. Toubi E et al (2004) Immune-mediated disorders associated with idiopathic sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol 113:445–449

    PubMed  Google Scholar 

  32. Seidman MD, Quirk WS, Shirwany NA (1999) Mechanisms of alterations in the microcirculation of the cochlea. Ann N Y Acad Sci 884:226–232

    CAS  PubMed  Google Scholar 

  33. Goodhill V (1971) Sudden deafness and round window rupture. Laryngoscope 81:1462–1474

    CAS  PubMed  Google Scholar 

  34. 2nd Pullen FW (1972) Round window membrane rupture: a cause of sudden deafness. Trans Am Acad Ophthalmol Otolaryngol 76:1444–1450

    PubMed  Google Scholar 

  35. Maier W, Fradis M, Kimpel S, Schipper J, Laszig R (2008) Results of exploratory tympanotomy following sudden unilateral deafness and its effects on hearing restoration. Ear Nose Throat J 87:438–451

    PubMed  Google Scholar 

  36. Masuda M et al (2012) Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol neurotol 33:1142–1150

    PubMed  Google Scholar 

  37. Fujioka M et al (2006) Proinflammatory cytokines expression in noise-induced damaged cochlea. J Neurosci Res 83:575–583

    CAS  PubMed  Google Scholar 

  38. Papa A et al (2008) Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clin Chim Acta Int J Clin Chem 395:27–31

    CAS  Google Scholar 

  39. Kuyumcu ME et al (2012) The evaluation of neutrophil-lymphocyte ratio in Alzheimer's disease. Dement Geriatr Cogn Disord 34:69–74

    PubMed  Google Scholar 

  40. Chen TM, Lin CC, Huang PT, Wen CF (2012) Neutrophil-to-lymphocyte ratio associated with mortality in early hepatocellular carcinoma patients after radiofrequency ablation. J Gastroenterol Hepatol 27:553–561

    CAS  PubMed  Google Scholar 

  41. Sertoglu E, Kayadibi H, Uyanik M (2015) Comment on "Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss". Dis Markers 2015:745879

    PubMed  PubMed Central  Google Scholar 

Download references

Funding

We do not have any funding support.

Author information

Authors and Affiliations

  1. Department of Otolaryngology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

    Shiyuan Wu & Bobei Chen

  2. The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China

    Shiyuan Wu, Fangling Shi & Bobei Chen

  3. Department of Otolaryngology, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China

    Zaizai Cao

Authors
  1. Shiyuan Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zaizai Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fangling Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bobei Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bobei Chen.

Ethics declarations

Conflict of interest

We do not have any conflict of Interest.

Ethical approval

Our study is a retrospective observational study, the institutional of ethics committee did not require formal approval.

Informed consent

Our study is a retrospective observational study, the informed consent did not require formal approval.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, S., Cao, Z., Shi, F. et al. Investigation of the prognostic role of neutrophil-to-lymphocyte ratio in Idiopathic Sudden Sensorineural Hearing Loss based on propensity score matching: a retrospective observational study. Eur Arch Otorhinolaryngol 277, 2107–2113 (2020). https://doi.org/10.1007/s00405-020-05905-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-020-05905-z

Keywords

Search

Navigation