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Clinical characteristics and surrogate markers of eosinophilic chronic rhinosinusitis in Southern China

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

The surrogate markers for subclassifying eosinophilic chronic rhinosinusitis (ECRS) and non-ECRS remain elusive. We herein performed a cross-sectional study to assess the clinical implication of clinical symptoms, CT findings, blood eosinophil (EOS) examination based on histological examination of tissue eosinophilia in 105 adult CRS patients (including 72 with nasal polyps and 33 without nasal polyps) in southern China. We found the mean score of smell loss was significantly higher in ECRS subgroup than those in non-ECRS subgroup (p < 0.05), whereas the average ethmoid osteitis index in non-ECRS subgroup was significantly higher than that in ECRS subgroup (p < 0.05). Moreover, we found both the mean blood EOS number and ratio were significantly higher in ECRS subgroup than those in non-ECRS subgroup (p < 0.05). By applying receiver operating characteristic (ROC) curve analysis, we found blood EOS number had a sensitivity of 84.9 % and specificity of 84.4 % [area under the curve (AUC): 0.873] at the cutoff level of 0.16 × 109/L, and blood EOS ratio had a sensitivity of 89.0 % and specificity of 84.4 % (AUC: 0.863) at the cutoff level of 2.05 % in this cohort. Our findings indicated that smell loss score, ethmoid osteitis index and blood EOS number and ratio may be used for the differential diagnosis of ECRS as the surrogate markers.

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Acknowledgments

This study was supported by the National Natural Science Fund of China (No. 81070771, 81070772, 81271054) and a grant from the Ministry of Hygiene (No. 201202005) and Program for New Century Excellent Talents in University (No. NCET-10-0851).

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No conflicts of interest to declare.

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Authors and Affiliations

  1. Allergy and Cancer Center, Otorhinolaryngology Hospital, The First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou, 510080, China

    Kejun Zuo, Jiebo Guo, Fenghong Chen, Rui Xu, Geng Xu, Jianbo Shi & Huabin Li

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  1. Kejun Zuo
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  2. Jiebo Guo
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  3. Fenghong Chen
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  4. Rui Xu
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  5. Geng Xu
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  6. Jianbo Shi
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  7. Huabin Li
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Corresponding author

Correspondence to Huabin Li.

Additional information

K. Zuo and J. Guo have contributed equally to this study.

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Zuo, K., Guo, J., Chen, F. et al. Clinical characteristics and surrogate markers of eosinophilic chronic rhinosinusitis in Southern China. Eur Arch Otorhinolaryngol 271, 2461–2468 (2014). https://doi.org/10.1007/s00405-014-2910-0

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  • DOI: https://doi.org/10.1007/s00405-014-2910-0

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