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Modulation of wireless (2.45 GHz)-induced oxidative toxicity in laryngotracheal mucosa of rat by melatonin

  • Laryngology
  • Published:
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Abstract

It is well known that oxidative stress induces larynx cancer, although antioxidants induce modulator role on etiology of the cancer. It is well known that electromagnetic radiation (EMR) induces oxidative stress in different cell systems. The aim of this study was to investigate the possible protective role of melatonin on oxidative stress induced by Wi-Fi (2.45 GHz) EMR in laryngotracheal mucosa of rat. For this purpose, 32 male rats were equally categorized into four groups, namely controls, sham controls, EMR-exposed rats, EMR-exposed rats treated with melatonin at a dose of 10 mg/kg/day. Except for the controls and sham controls, the animals were exposed to 2.45 GHz radiation during 60 min/day for 28 days. The lipid peroxidation levels were significantly (p < 0.05) higher in the radiation-exposed groups than in the control and sham control groups. The lipid peroxidation level in the irradiated animals treated with melatonin was significantly (p < 0.01) lower than in those that were only exposed to Wi-Fi radiation. The activity of glutathione peroxidase was lower in the irradiated-only group relative to control and sham control groups but its activity was significantly (p < 0.05) increased in the groups treated with melatonin. The reduced glutathione levels in the mucosa of rat did not change in the four groups. There is an apparent protective effect of melatonin on the Wi-Fi-induced oxidative stress in the laryngotracheal mucosa of rats by inhibition of free radical formation and support of the glutathione peroxidase antioxidant system.

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Conflict of interest

None of the authors has any conflict of interest, financial or otherwise.

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Authors and Affiliations

  1. Ear, Nose and Throat, Head and Neck Surgery Department, School of Medicine, Suleyman Demirel University, Isparta, Turkey

    Giray Aynali, Murat Yarıktaş & Hasan Yasan

  2. Biophysics Department, School of Medicine, Suleyman Demirel University, Isparta, Turkey

    Mustafa Nazıroğlu & Ömer Çelik

  3. Ear, Nose and Throat, Head and Neck Surgery Department, Isparta State Hospital, Isparta, Turkey

    Mustafa Doğan

  4. Modernevler Mah. Çevre Yolu 142. Cad. No. 7 İksir Apt D :7, 32200, Isparta, Turkey

    Giray Aynali

Authors
  1. Giray Aynali
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  2. Mustafa Nazıroğlu
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  3. Ömer Çelik
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  4. Mustafa Doğan
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  5. Murat Yarıktaş
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  6. Hasan Yasan
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Correspondence to Giray Aynali.

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Aynali, G., Nazıroğlu, M., Çelik, Ö. et al. Modulation of wireless (2.45 GHz)-induced oxidative toxicity in laryngotracheal mucosa of rat by melatonin. Eur Arch Otorhinolaryngol 270, 1695–1700 (2013). https://doi.org/10.1007/s00405-013-2425-0

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  • DOI: https://doi.org/10.1007/s00405-013-2425-0

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