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TNF-α-308G/A polymorphisms and nasopharyngeal cancer risk: a meta-analysis

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Previous evidence has indicated that the polymorphism of tumor necrosis factor-alpha (TNF-α) is a risk factor for various cancers, however, the association between TNF-α-308G/A polymorphism and nasopharyngeal carcinoma (NPC) remains controversial and ambiguous. The aim of this study is to clarify the association between TNF-α polymorphism and NPC using meta-analysis. A meta-analysis based on five eligible case–control studies involving 499 cases and 1,470 controls was carried out to summarize the data on the association between TNF-α-308G/A polymorphism and NPC risk. Odds ratios (OR) with 95 % confidence intervals (95 % CI) were used to assess the strength of this association in the fixed-effect model. The pooled analyses showed no significant association between TNF-α-308G/A polymorphism and NPC (AA vs. GG: OR = 1.38, P = 0.193; GA vs. GG: OR = 0.92, P = 0.585; GA + AA vs. GG: OR = 1.00, P = 0.972; AA vs. GA + GG: OR = 1.44, P = 0.138). We also categorized by geographic location (non-Asian or Asian) for subgroup analysis; the results also showed no significant association between TNF-α-308G/A polymorphism and NPC risk in all of the comparisons. No publication bias was observed in this study (t = −0.11, P = 0.918, 95 % CI = −4.893–4.559). No significant association was found between TNF-α-308G/A polymorphism and the risk for NPC.

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Acknowledgments

All of the authors are grateful to Professor Zhi-ping Chen for his constructive criticism on an earlier draft of this manuscript, and for the integrity of the data and the accuracy of the data analysis.

Conflict of interest

No competing financial interests exist.

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Authors and Affiliations

  1. Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China

    Li Xie, Yan Deng, Xue Qin & Shan Li

  2. Department of Orthopaedics Trauma and Hand Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China

    Xiao-Nan Liang

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  1. Li Xie
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  2. Xiao-Nan Liang
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  3. Yan Deng
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  4. Xue Qin
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  5. Shan Li
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Corresponding authors

Correspondence to Xue Qin or Shan Li.

Additional information

L. Xie and X.-N. Liang contributed equally to this work.

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Xie, L., Liang, XN., Deng, Y. et al. TNF-α-308G/A polymorphisms and nasopharyngeal cancer risk: a meta-analysis. Eur Arch Otorhinolaryngol 270, 1667–1672 (2013). https://doi.org/10.1007/s00405-012-2276-0

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  • DOI: https://doi.org/10.1007/s00405-012-2276-0

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