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Relationship between the mechanism of hepatitis B virus father–infant transmission and pregnancy outcome

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

This study examined the relationship between the mechanism of hepatitis B virus (HBV) father–infant transmission via reproductive cells and pregnancy outcome.

Methods

Abandoned in vitro fertilization (IVF) embryos of fathers with chronic HBV infection were taken as study objects. HBV mRNA in embryos was detected, and successfully transplanted embryos were followed up to determine the relationship between HBV-infected embryos and pregnancy outcome.

Results

HBV mRNA signals were detected in one embryo in the group with HBV-positive fathers; the positive rate was 1/18 (5.5%). IVF embryos of HBV-positive fathers with HBV mRNA signals were successfully implanted, but early abortion occurred.

Conclusions

HBV mRNA was found in abandoned IVF embryos of HBV-infected fathers, which confirmed that HBV could not only enter early cleavage embryos via sperm but also replicate in embryos, resulting in HBV father–infant transmission. HBV may interfere with embryonic development and thus affect pregnancy outcome.

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Acknowledgements

This study was supported by National Natural Science Foundation of China (No. 30371277).

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Authors and Affiliations

  1. Departments of Infectious Disease and Gynecology and Obstetrics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China

    Ying Kong, Yi Liu, Xiaojing Liu, Zirong Zhu, Aiyun Zhang, Jianxue Liu, Feng Ye & Shumei Lin

  2. Department of Reproductive Center, Shaanxi Maternal and Child Care Hospital, Xi’an, 710061, China

    Na Li

Authors
  1. Ying Kong
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  2. Yi Liu
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  3. Xiaojing Liu
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  4. Na Li
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  5. Zirong Zhu
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  6. Aiyun Zhang
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  7. Jianxue Liu
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  8. Feng Ye
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  9. Shumei Lin
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Corresponding authors

Correspondence to Feng Ye or Shumei Lin.

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Ethical approval

This study was conducted in accordance with the declaration of Helsinki. This study was conducted with approval from the Ethics Committee of The First Affiliated Hospital of Xi’an Jiaotong University. Written informed consent was obtained from all participants.

Conflict of interest

We declare that we have no conflict of interest.

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Cite this article

Kong, Y., Liu, Y., Liu, X. et al. Relationship between the mechanism of hepatitis B virus father–infant transmission and pregnancy outcome. Arch Gynecol Obstet 295, 253–257 (2017). https://doi.org/10.1007/s00404-016-4231-6

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  • DOI: https://doi.org/10.1007/s00404-016-4231-6

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