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Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model

  • General Gynecology
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Abstract

Purpose

The aim of the present study is to evaluate the treatment potential of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in the experimentally induced endometriosis model in rats.

Methods

Endometriosis was surgically induced in rats by autotransplanting endometrial tissue to abdominal wall. Thirty-six rats were randomly divided into six groups. The groups were orally treated with the methanol:water (80:20) extracts of aerial parts and roots of A. mollis and A. persica. Buserelin acetate (20 mg) was used as the reference drug. The phytochemical contents of the most active extracts were determined by high performance liquid chromatography.

Results

The cystic formation was determined to be significantly decreased with the aerial part extract of A. mollis. A reduction in the endometrioma was also determined for the aerial part extract of A. persica group. However, significant reduction on the levels of cytokine were recorded for the A. mollis aerial part extract group. Therefore, the phytochemical contents of the aerial part extracts of A. mollis. and A. persica were analyzed.

Conclusion

The results of the present study revealed that the aerial part extracts of A. mollis and A. persica could be beneficial in the treatment of endometriosis.

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Authors and Affiliations

  1. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 06330, Ankara, Turkey

    Esra Küpeli Akkol, Ipek Süntar & Mert Ilhan

  2. Laboratory Animals Breeding and Experimental Researches Center, Faculty of Pharmacy, Gazi University, Etiler, 06330, Ankara, Turkey

    Murside Ayse Demirel

  3. Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100, Tandoğan-Ankara, Turkey

    Ozlem Bahadır Acıkara, Burcin Ergene, Serkan Ozbilgin & Gulcin Saltan

  4. Department of Pathology, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey

    Hikmet Keleş

  5. Department of Biology, Faculty of Science, Cumhuriyet University, 58140, Sivas, Turkey

    Mehmet Tekin

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  1. Esra Küpeli Akkol
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Küpeli Akkol, E., Demirel, M.A., Bahadır Acıkara, O. et al. Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model. Arch Gynecol Obstet 292, 619–628 (2015). https://doi.org/10.1007/s00404-015-3665-6

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