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Is there an association between liver type fatty acid binding protein and severity of preeclampsia?

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

The aim of this study was to estimate the level of liver fatty acid binding protein (LFABP) in women with preeclampsia.

Method

A case–control study was conducted in 90 pregnant women who were divided into the following three groups: normal pregnancy (n = 30), mild–moderate preeclampsia (n = 30), and severe preeclampsia (n = 30). Maternal blood samples were obtained during an antenatal clinic visit in normal pregnant women, and at the time of diagnosis in women with preeclampsia. Serum LFABP levels were measured by the quantitative sandwich enzyme immunoassay technique.

Results

Serum LFABP level was significantly higher in severe and mild–moderate preeclampsia groups than normal pregnancy group (1,709.90 ± 94.82, 1,614.93 ± 118.22, and 1,532.36 ± 140.98 pg/ml, respectively; p < 0.001). In multivariate analysis, the severity of preeclampsia was correlated with LFABP level [unadjusted odds ratio (95 % confidence interval), 1.008 (1.003–1.012), p < 0.001 and LDH 1.063 (1.029–1.099), p < 0.001].

Conclusion

Maternal serum LFABP level appears to be correlated with the severity of the preeclampsia and can be used to confirm the diagnosis.

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Conflict of interest

The authors have no conflict of interest.

Author information

Authors and Affiliations

  1. Obstetrics and Gynecology Department, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey

    Ozlem Uzunlar, Yaprak Engin-Ustun, Sebnem Ozyer, Nuri Danısman & Senem M. Keskin

  2. Obstetrics and Gynecology Department, Etlik Zubeyde Hanim Dogumevi Women Health Training and Research Hospital, Ankara, Turkey

    Leyla Mollamahmutoglu

  3. Department of Medical Biochemistry, Medical School of the Ufuk University, Ankara, Turkey

    Tuba Candar

Authors
  1. Ozlem Uzunlar
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  2. Yaprak Engin-Ustun
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  3. Sebnem Ozyer
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  4. Nuri Danısman
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  5. Tuba Candar
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  6. Senem M. Keskin
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  7. Leyla Mollamahmutoglu
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Correspondence to Ozlem Uzunlar.

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Uzunlar, O., Engin-Ustun, Y., Ozyer, S. et al. Is there an association between liver type fatty acid binding protein and severity of preeclampsia?. Arch Gynecol Obstet 291, 1069–1074 (2015). https://doi.org/10.1007/s00404-014-3540-x

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  • DOI: https://doi.org/10.1007/s00404-014-3540-x

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