Abstract
Objective
To evaluate the use of third trimester inhibin A levels to assess the severity of preeclampsia.
Materials and methods
Blood samples were taken from women diagnosed with mild and severe preeclampsia during the third trimester of pregnancy. Blood samples were collected in plain tubes, centrifuged and stored at −80°C until analyzed. All serum samples were measured for inhibin A levels by enzyme-linked immunosorbent assays.
Results
Inhibin A levels were greater in the severe (1,435.9 ± 603.2 pg/mL) than in the mild preeclampsia group (1,021.9 ± 438.8 pg/mL, P = 0.014).
Conclusion
Inhibin A levels rise with increasing severity of disease. However, there is considerable overlap of serum inhibin A levels in women with mild and severe preeclampsia. Inhibin A is therefore not a useful adjunct for the classification of preeclampsia.
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Acknowledgment
This work was supported by a grant, number PP03/50, from the Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University.
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Phupong, V., Paiwattananupant, K. & Honsawek, S. Inhibin A levels and severity of preeclampsia. Arch Gynecol Obstet 280, 183–186 (2009). https://doi.org/10.1007/s00404-008-0886-y
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DOI: https://doi.org/10.1007/s00404-008-0886-y