Archives of Dermatological Research

, Volume 289, Issue 3, pp 125–131

Density and fine structure of peripheral nerves in various skin lesions of atopic dermatitis

  • H. Sugiura
  • Mitsuyoshi Omoto
  • Yusuke Hirota
  • Kiichiro Danno
  • Masami Uehara
Original paper

DOI: 10.1007/s004030050167

Cite this article as:
Sugiura, H., Omoto, M., Hirota, Y. et al. Arch Dermatol Res (1997) 289: 125. doi:10.1007/s004030050167

Abstract

The density and fine structure of the peripheral nerve system in various skin lesions of 64 patients with atopic dermatitis (AD) was quantitatively analyzed by immunohistochemical staining with antibodies directed against protein gene product (PGP) and substance P (SP). The density of PGP-positive peripheral nerves was 2.5 × 103μm2/Δs (Δs = 0.24 mm2 selected area) in early acute lesions, 3.8 × 103μm2/Δs in subacute lesions, 4.9 × 103μm2/Δs in lichenified lesions and 7.1 × 103μm2/Δs in prurigo lesions of AD. The density of nerve fibers in subacute, lichenified and prurigo lesions was significantly higher than in uninvolved skin of AD patients (2.0 × 103μm2/Δs). Electron microscopically, bulging of axons with many mitochondria and a loss of their surrounding sheath of Schwann cells suggests that the free nerve endings in skin lesions of AD are in an active state of excitation. Many pinocytotic vesicles in the periphery of basal keratinocytes facing nerve endings which contained many neurovesicles suggests reciprocal effects between keratinocytes and nerve endings. The number of SP-positive nerve fibers in AD lesions was far less than one-tenth of the number of PGP-positive nerve fibers.

Key words Atopic dermatitisPeripheral nerveElectron microscopyProtein gene productSubstance P

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • H. Sugiura
    • 1
  • Mitsuyoshi Omoto
    • 1
  • Yusuke Hirota
    • 1
  • Kiichiro Danno
    • 1
  • Masami Uehara
    • 1
  1. 1.Department of Dermatology, Shiga University of Medical Science Seta, Otsu 520-21 Japan Tel. (81)-775-48-2234; Fax (81)-775-45-2943JP