Archives of Dermatological Research

, Volume 292, Issue 10, pp 477–481

Glycine substitution mutations by different amino acids in the same codon of COL7A1 lead to heterogeneous clinical phenotypes of dominant dystrophic epidermolysis bullosa

Authors

  • T. Murata
    • Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan e-mail: takayuki@med.keio.ac.jp, Tel.: +81-3-33531211, Fax: +81-3-33516880
  • T. Masunaga
    • Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan e-mail: takayuki@med.keio.ac.jp, Tel.: +81-3-33531211, Fax: +81-3-33516880
  • H. Shimizu
    • Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan
  • Y. Takizawa
    • Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan e-mail: takayuki@med.keio.ac.jp, Tel.: +81-3-33531211, Fax: +81-3-33516880
  • A Ishiko
    • Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan e-mail: takayuki@med.keio.ac.jp, Tel.: +81-3-33531211, Fax: +81-3-33516880
  • N. Hatta
    • Department of Dermatology, Kanazawa University School of Medicine, Kanazawa, Japan
  • T. Nishikawa
    • Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan e-mail: takayuki@med.keio.ac.jp, Tel.: +81-3-33531211, Fax: +81-3-33516880
Original Paper

DOI: 10.1007/s004030000162

Cite this article as:
Murata, T., Masunaga, T., Shimizu, H. et al. Arch Dermatol Res (2000) 292: 477. doi:10.1007/s004030000162

Abstract Dystrophic epidermolysis bullosa (DEB), caused by mutations in the gene encoding type VII collagen (COL7A1), is known to show heterogeneous clinical phenotypes. Certain correlations between the nature or position of COL7A1 mutations and the resultant DEB phenotypes have been suggested, although such relationships may be more complex than initially thought. The purpose of the present study was to clarify the molecular basis of two different subtypes of dominant DEB (DDEB), EB pruriginosa and classical type. Interestingly, we found that both cases were caused by a missense glycine substitution mutation by different amino acids in the same codon of COL7A1 (G2028R and G2028A). These results further support the notion that different glycine substitution mutations in the same codon can lead to heterogeneous clinical phenotypes of DDEB, EB pruriginosa and classical type.

Key words Type VII collagenPruriginosaAnchoring fibrilBasement membrane

Copyright information

© Springer-Verlag Berlin Heidelberg 2000