Archives of Dermatological Research

, Volume 302, Issue 7, pp 507–515

GABA and GABAA receptor expression on immune cells in psoriasis: a pathophysiological role

  • Rishi Nigam
  • Husameldin El-Nour
  • Beni Amatya
  • Klas Nordlind
Original Paper

DOI: 10.1007/s00403-010-1052-5

Cite this article as:
Nigam, R., El-Nour, H., Amatya, B. et al. Arch Dermatol Res (2010) 302: 507. doi:10.1007/s00403-010-1052-5

Abstract

Psoriasis is a chronic inflammatory disease in which pruritus is a common symptom. Pruritus may be associated with the gamma-aminobutyric acid (GABA) system. The distribution of GABA and its GABAA receptor (R) was studied in involved and non-involved psoriatic skin, as well as normal healthy control skin, using an immunohistochemistry technique. Pruritus was determined using a visual analog scale. Inflammatory cells immunoreactive for the GABA ligand and the GABAA R were increased (P < 0.01, respectively) in the involved skin. Cells stained for GABA ligand were mostly macrophages with some lymphocytes, while cells stained for GABAA R were macrophages, neutrophils or lymphocytes. There was a positive correlation when comparing GABA ligand (P = 0.05) and GABAA R (P < 0.05) expressing inflammatory cells, with pruritus. The GABA ligand and its GABAA R may play a role for the pathogenesis of psoriasis as well as for pruritus in this disease.

Keywords

GABAGABA receptorPruritusPsoriasis

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Rishi Nigam
    • 1
  • Husameldin El-Nour
    • 1
  • Beni Amatya
    • 1
  • Klas Nordlind
    • 1
  1. 1.Dermatology and Venereology Unit, Department of MedicineSolna, Karolinska University Hospital, Karolinska InstitutetStockholmSweden