Skip to main content
SpringerLink
Log in

Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts

  • Correspondence
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E (2003) Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 24:197–211. doi:10.1016/S0197-4580(02)00065-9

    Article  PubMed  Google Scholar 

  2. Fritschi SK, Clintron A, Ye L, Mahler J, Bühler A, Baumann F, Neumann M, Nilsson KP, Hammarström P, Walker LC, Jucker M (2014) Aβ seeds resist inactivation by formaldehyde. Acta Neuropathol 128:477–484. doi:10.1007/s00401-014-1339-2

    Article  CAS  PubMed  Google Scholar 

  3. Goedert M, Spillantini MG, Del Tredici K, Braak H (2013) 100 years of Lewy pathology. Nat Rev Neurol 9:13–24. doi:10.1038/nrneurol.2012.242

    Article  CAS  PubMed  Google Scholar 

  4. Guo JL, Lee VM-Y (2014) Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases. Nat Med 20:130–138. doi:10.1038/nm.3457

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Jucker M, Walker LC (2013) Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature 501:45–51. doi:10.1038/nature12481

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Luk KC, Kehm VM, Zhang B, O´Brien P, Trojanowski JQ, Lee VM-Y (2012) Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med 209:975–986. doi:10.1084/jem.20112457

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, Mann DM, Hasegawa M (2013) Prion-like spreading of pathological α-synuclein in brain. Brain 136:1128–1138. doi:10.1093/brain/awt037

    Article  PubMed Central  PubMed  Google Scholar 

  8. Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret J-M, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M (2006) Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science 313:1781–1784. doi:10.1126/science.1131864

    Article  CAS  PubMed  Google Scholar 

  9. Neumann M, Kahle PJ, Giasson BI (2002) Misfolded proteinase K-resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies. J Clin Invest 110:1429–1439. doi:10.1172/JCI200215777

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Van der Putten H, Wiederhold K-H, Probst A, Barbieri S, Mistl C, Danner S, Kauffmann S, Hofele K, Spooren WP, Ruegg MA, Lin S, Caroni P, Sommer B, Tolnay M, Bilbe G (2000) Neuropathology in mice expressing human α-synuclein. J Neurosci 20:6021–6029

    PubMed  Google Scholar 

Download references

Acknowledgments

We thank Lary Walker (Atlanta) and laboratory members for help. Animal experiments were approved and in accordance with the local regulations.

Author information

Authors and Affiliations

  1. German Center for Neurodegenerative Diseases (DZNE), 72076, Tübingen, Germany

    Manuel Schweighauser, Mehtap Bacioglu, Sarah K. Fritschi, Philipp J. Kahle, Yvonne S. Eisele & Mathias Jucker

  2. Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076, Tübingen, Germany

    Manuel Schweighauser, Mehtap Bacioglu, Sarah K. Fritschi, Yvonne S. Eisele & Mathias Jucker

  3. Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, 72074, Tübingen, Germany

    Manuel Schweighauser, Mehtap Bacioglu & Sarah K. Fritschi

  4. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076, Tübingen, Germany

    Philipp J. Kahle

  5. Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4002, Basel, Switzerland

    Derya R. Shimshek

Authors
  1. Manuel Schweighauser
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mehtap Bacioglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sarah K. Fritschi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Derya R. Shimshek
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Philipp J. Kahle
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yvonne S. Eisele
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mathias Jucker
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mathias Jucker.

Additional information

M. Schweighauser and M. Bacioglu contributed equally to this work.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PDF 1257 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schweighauser, M., Bacioglu, M., Fritschi, S.K. et al. Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts. Acta Neuropathol 129, 157–159 (2015). https://doi.org/10.1007/s00401-014-1360-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00401-014-1360-5

Keywords

Search

Navigation