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Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types

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Acknowledgments

This work was funded by grants from The Brain Tumour Charity, North of England Children’s Cancer Research (NECCR), CLIC-Sargent, The James Tudor and Joe Foote Foundations, The Gentleman’s Night Out and Cancer Research UK. Tumours investigated in this study include samples provided by the UK Children’s Cancer and Leukaemia Group (CCLG) as part of CCLG-approved biological study BS-2007-04. This study was conducted with ethics committee approval from Newcastle/North Tyneside REC (study reference 07/Q0905/71) and Trent REC (04/MRE04/72).

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Authors and Affiliations

  1. Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK

    Ed. C. Schwalbe, James T. Hayden, Janet C. Lindsey, Rebecca M. Hill, Sarah-Leigh Nicholson, Daniel Williamson, Simon Bailey & Steven C. Clifford

  2. Children’s Brain Tumour Research Centre, Queen’s Medical Centre, University of Nottingham, Nottingham, UK

    Hazel A. Rogers, Suzanne Miller, John-Paul Kilday, Martyna Adamowicz-Brice, Lisa Storer, Keith Robson, Jim Lowe & Richard G. Grundy

  3. Neural Development Unit, Birth Defect Research Centre, UCL Institute of Child Health, London, UK

    Thomas S. Jacques

  4. Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

    Thomas S. Jacques

Authors
  1. Ed. C. Schwalbe
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  2. James T. Hayden
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  3. Hazel A. Rogers
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  4. Suzanne Miller
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  5. Janet C. Lindsey
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  6. Rebecca M. Hill
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  7. Sarah-Leigh Nicholson
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  8. John-Paul Kilday
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  9. Martyna Adamowicz-Brice
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  10. Lisa Storer
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  11. Thomas S. Jacques
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  12. Keith Robson
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  13. Jim Lowe
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  14. Daniel Williamson
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  15. Richard G. Grundy
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  16. Simon Bailey
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  17. Steven C. Clifford
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Corresponding author

Correspondence to Steven C. Clifford.

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Schwalbe, E.C., Hayden, J.T., Rogers, H.A. et al. Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types. Acta Neuropathol 126, 943–946 (2013). https://doi.org/10.1007/s00401-013-1206-6

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  • DOI: https://doi.org/10.1007/s00401-013-1206-6

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