, Volume 117, Issue 5, pp 467-468
Date: 13 Mar 2009

Brain plasticity after ischemic stroke: an update

This is an excerpt from the content

When I started my training in neuropathology almost 20 years ago, I was slightly disappointed by the rather small number of neurodegenerative autopsy cases. Instead, at that time, cerebral ischemia represented the focus of investigation at this laboratory. These days, however, I find it surprising that ischemia research appears to vanish in the realm of neuropathology. Neurodegenerative diseases are certainly frequent and literally represent the core of neuropathology. Furthermore, tumor biopsy cases, despite their rare total incidence, are undoubtedly of major importance of how modern neuropathology defines itself. Nevertheless, the mere look at the huge number of patients dying from cerebral ischemia, both global and focal,—as, e.g., seen after cardiac arrest or ischemic stroke, respectively—renders the latter the most common group of diseases where the brain is involved. Consider the following facts when taking only stroke into account, which is ischemic in about 85% of cases [10]: