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Alzheimer pathology associated with POLG1 mutation, multiple mtDNA deletions, and APOE4/4: premature ageing or just coincidence?

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Fig. 1 a

References

  1. Calabrese V, Scapagnini G, Giuffrida Stella AM, Bates TE, Clark JB (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochem Res 26:739–764

    Article  CAS  PubMed  Google Scholar 

  2. Jorm AF, Korten AE, Henderson AS (1987) The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr Scand 76:465–479

    CAS  PubMed  Google Scholar 

  3. Luoma P, Melberg A, Rinne JO, Kaukonen JA, Nupponen NN, Chalmers RM, Oldfors A, Rautakorpi I, Peltonen L, Majamaa K, Somer H, Suomalainen A (2004) Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. Lancet 364:875–882

    Article  CAS  PubMed  Google Scholar 

  4. Moslemi AR, Melberg A, Holme E, Oldfors A (1996) Clonal expansion of mitochondrial DNA with multiple deletions in autosomal dominant progressive external ophthalmoplegia. Ann Neurol 40:707–713

    Google Scholar 

  5. Moslemi AR, Melberg A, Holme E, Oldfors A (1999) Autosomal dominant progressive external ophthalmoplegia: distribution of multiple mitochondrial DNA deletions. Neurology 53:79–84

    CAS  PubMed  Google Scholar 

  6. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly YM, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacobs HT, Larsson NG (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417–423

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by the Selander Foundation, the Ländell Foundation, and the Swedish Research Council (Proj. no. 7122 and 10823).

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Authors and Affiliations

  1. Department of Neuroscience and Neurology, University Hospital, 751 85, Uppsala, Sweden

    Atle Melberg

  2. Department of Pathology, Karolinska University Hospital, 141 86, Stockholm, Sweden

    Inger Nennesmo

  3. Department of Pathology, Sahlgrenska University Hospital, 413 45, Göteborg, Sweden

    Ali-Reza Moslemi, Gittan Kollberg & Anders Oldfors

  4. Department of Neurology and Programme of Neurosciences, University of Helsinki, 00290, Helsinki, Finland

    Petri Luoma & Anu Suomalainen

  5. Department of Clinical Chemistry, Sahlgrenska University Hospital, 413 45, Göteborg, Sweden

    Elisabeth Holme

Authors
  1. Atle Melberg
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  2. Inger Nennesmo
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  3. Ali-Reza Moslemi
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  4. Gittan Kollberg
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  5. Petri Luoma
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  7. Elisabeth Holme
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  8. Anders Oldfors
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Corresponding author

Correspondence to Anders Oldfors.

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Melberg, A., Nennesmo, I., Moslemi, AR. et al. Alzheimer pathology associated with POLG1 mutation, multiple mtDNA deletions, and APOE4/4: premature ageing or just coincidence?. Acta Neuropathol 110, 315–316 (2005). https://doi.org/10.1007/s00401-005-1047-z

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  • DOI: https://doi.org/10.1007/s00401-005-1047-z

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