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Dynamic and rheological properties of soft biological cell suspensions

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Abstract

Quantifying dynamic and rheological properties of suspensions of soft biological particles such as vesicles, capsules, and red blood cells (RBCs) is fundamentally important in computational biology and biomedical engineering. In this review, recent studies on dynamic and rheological behavior of soft biological cell suspensions by computer simulations are presented, considering both unbounded and confined shear flow. Furthermore, the hemodynamic and hemorheological characteristics of RBCs in diseases such as malaria and sickle cell anemia are highlighted.

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Acknowledgments

We acknowledge support from the National Institutes of Health (NIH) grants U01HL114476 and U01HL116323. A.Y. acknowledges TACC/STAMPEDE resources through XSEDE grant (TG-DMS140007), and X.L. acknowledges ALCF through INCITE program for providing computational resources that have lead to the unpublished research results reported within this paper.

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Authors and Affiliations

  1. Division of Applied Mathematics, Brown University, Providence, Rhode Island, 02912, USA

    Alireza Yazdani, Xuejin Li & George Em Karniadakis

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  1. Alireza Yazdani
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  2. Xuejin Li
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  3. George Em Karniadakis
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Correspondence to George Em Karniadakis.

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This paper belongs to the special issue on the “Rheology of blood cells, capsules and vesicles.”

These authors contributed equally to this work.

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Yazdani, A., Li, X. & Karniadakis, G.E. Dynamic and rheological properties of soft biological cell suspensions. Rheol Acta 55, 433–449 (2016). https://doi.org/10.1007/s00397-015-0869-4

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  • DOI: https://doi.org/10.1007/s00397-015-0869-4

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