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Engineering polyethersulfone hollow fiber membrane with improved blood compatibility and antibacterial property

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Abstract

Hollow fiber membranes with satisfied blood compatibility and antibacterial property are desired in blood purification. Herein, a series of heparin-like copolymers of poly(methyl methacrylate-vinyl pyrrolidone -sodium styrene sulfonate-sodium acrylate) (poly(MMA-VP-SSNa-SA)) were synthesized by free radical solution polymerization. The mixture was directly blended with polyethersulfone (PES) solution to prepare hollow fiber membranes. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Blood compatibility of the hollow fiber membranes was evaluated via protein adsorption, platelet adhesion, clotting time, and hemolysis assay. Besides, Ag nanoparticles were immobilized onto the hollow fiber membranes efficiently by a simple and green method, and the antibacterial property and blood compatibility of the Ag-loaded membranes were then investigated. The results indicated that the approach towards blood compatible and antibacterial hollow fiber membrane is efficient and flexible for the modification for membrane materials.

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Acknowledgments

This work was financially sponsored by the National Natural Science Foundation of China (Nos. 51225303 and 51433007) and the State Key Laboratory of Polymer Materials Engineering (No. sklpme2015-1-03). We should also thank our laboratory members for their generous help and gratefully acknowledge the help of Ms. Hui Wang of the Analytical and Testing Center at Sichuan University.

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Authors and Affiliations

  1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China

    Zhen-Qiang Shi, Hai-Feng Ji, Hai-Chao Yu, Xue-Lian Huang, Wei-Feng Zhao, Shu-Dong Sun & Chang-Sheng Zhao

  2. Fiber and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology (KTH), Teknikringen 56-58, 100 44, Stockholm, Sweden

    Wei-Feng Zhao

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  1. Zhen-Qiang Shi
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  2. Hai-Feng Ji
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Correspondence to Shu-Dong Sun or Chang-Sheng Zhao.

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Shi, ZQ., Ji, HF., Yu, HC. et al. Engineering polyethersulfone hollow fiber membrane with improved blood compatibility and antibacterial property. Colloid Polym Sci 294, 441–453 (2016). https://doi.org/10.1007/s00396-015-3801-7

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  • DOI: https://doi.org/10.1007/s00396-015-3801-7

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