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Biofunctionalisation of colloidal gold nanoparticles via polyelectrolytes assemblies

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Abstract

Bioapplications of gold nanoparticles (Au NPs) have received significant attention due to their sensitive optical characteristics which depend on particle size and shape, state of aggregation and to surrounding (bio)chemical environment. In this review, we present an overview of several methods to synthesise stable colloidal Au NPs with focus on the use of the electrostatic assembly method of polyelectrolytes (PE) to functionalise Au NPs. This versatile method allows adjusting the thickness, chemical functions and the surface charge of the shells surrounding the Au NPs, thus the relevance of these features for the bioapplications of Au NPs involving surface-mediated processes is discussed. Moreover, because the PE used can be functionalised with organic fluorophores, drugs or antibodies yielding multifunctional nanocomposites useful for those applications, this review also provides an overview of the electrostatic assembly of functionalised PE onto Au NPs and their bioapplications.

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Abbreviations

B-PEI:

Branched poly(ethylenimine)

DMAP:

(4-(dimethylamino)pyridine)

DNA:

Deoxyribonucleic acid

EDC:

(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

FITC:

Fluorescein isothiocyanate

HPMA:

N-(2-hydroxypropyl)methacrylamide

IgG:

Immunoglobulin G

LISS:

Lissamine rhodamine B

L-PEI:

Linear poly(ethyleneimine)

MUA:

Mercaptoundecanoic acid

NHS:

N-hydroxysuccinimide

NPs:

Nanoparticles

PAA:

Poly(allylamine)

PAAcid:

Poly(acrylic acid)

PAH:

Poly(allylamine hydrochloride)

PBS:

Phosphate-buffered saline

PCs/NP:

Polyelectrolyte chains per NPs

PDADMAC:

Poly(diallyldimethylammonium chloride)

PE:

Polyelectrolyte

PEI:

Poly(ethyleneimine)

PLL:

Poly(L-lysine)

PSS:

Poly(styrenesulfonic acid sodium salt)

Si-PEI:

N-[3-(trimethoxysilyl)propyl] poly(ethylenimine)

SPR:

Surface plasmon resonance

siRNA:

Small interfering RNA

TEM:

Transmission electron microscopy

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Acknowledgments

Sónia Pereira thanks Fundação para a Ciência e Tecnologia (FCT) for the grant SFRH/BD/80156/2011. CICECO acknowledges funding from FCT, FSE and POPH (Pest-C/CTM/LA0011/2011 project).

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  1. Department of Chemistry-CICECO Aveiro Institute of Nanotechnology, University of Aveiro, 3810-193, Aveiro, Portugal

    Sónia O. Pereira, Ana Barros-Timmons & Tito Trindade

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  1. Sónia O. Pereira
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  2. Ana Barros-Timmons
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  3. Tito Trindade
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Correspondence to Tito Trindade.

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Pereira, S.O., Barros-Timmons, A. & Trindade, T. Biofunctionalisation of colloidal gold nanoparticles via polyelectrolytes assemblies. Colloid Polym Sci 292, 33–50 (2014). https://doi.org/10.1007/s00396-013-3037-3

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  • DOI: https://doi.org/10.1007/s00396-013-3037-3

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