European Journal of Nutrition

, Volume 53, Issue 1, pp 73–82

Ilex paraguariensis (yerba mate) improves endocrine and metabolic disorders in obese rats primed by early weaning

Authors

  • Natália da S. Lima
    • Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology InstituteState University of Rio de Janeiro
  • Juliana G. Franco
    • Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology InstituteState University of Rio de Janeiro
  • Nayara Peixoto-Silva
    • Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology InstituteState University of Rio de Janeiro
  • Lígia A. Maia
    • Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology InstituteState University of Rio de Janeiro
  • Andrea Kaezer
    • Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology InstituteState University of Rio de Janeiro
    • Department of Biophysics and Biometry, Roberto Alcantara Gomes Biology InstituteState University of Rio de Janeiro
  • Israel Felzenszwalb
    • Department of Biophysics and Biometry, Roberto Alcantara Gomes Biology InstituteState University of Rio de Janeiro
  • Elaine de Oliveira
    • Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology InstituteState University of Rio de Janeiro
  • Egberto G. de Moura
    • Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology InstituteState University of Rio de Janeiro
    • Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology InstituteState University of Rio de Janeiro
    • Departamento de Ciências Fisiológicas, 5° andar, Instituto de BiologiaUniversidade do Estado do Rio de Janeiro
Original Contribution

DOI: 10.1007/s00394-013-0500-3

Cite this article as:
Lima, N.d.S., Franco, J.G., Peixoto-Silva, N. et al. Eur J Nutr (2014) 53: 73. doi:10.1007/s00394-013-0500-3

Abstract

Purpose

We showed that early weaned rats developed obesity, hyperleptinemia, leptin and insulin resistance at adulthood. Here, we studied the potential beneficial effects of Ilex paraguariensis aqueous solution upon body composition, glycemia, lipid and hormonal profiles, leptin signaling and NPY content.

Methods

To induce early weaning, lactating rats’ teats were blocked with a bandage to interrupt lactation during the last 3 days (EW group), while control offspring had free access to milk throughout lactation (C group). In postnatal day (PN) 150, EW offspring were subdivided into: EW and EW+ mate groups treated, respectively, with water or yerba mate aqueous solution (1 g/kg BW/day, gavage) during 30 days. C offspring received water for gavage. In PN180, offspring were killed.

Results

EW+ mate group presented lower body weight (−10 %), adipose mass (retroperitoneal:−40 % and epididymal:−44 %), total body fat (−43 %), subcutaneous fat (−46 %), visceral adipocyte area (−21 %), triglyceridemia (−31 %) and hypothalamic NPY content (−37 %) compared to EW group. However, hyperglycemia and lower HDL-c levels observed in EW group were not reverted with mate treatment. Although the hyperleptinemia, lower hypothalamic JAK2 and pSTAT3 content of EW group were not corrected by mate treatment, the hyperphagia and higher hypothalamic SOCS-3 content were normalized in EW+ mate group, indicating that the central leptin resistance could be restored.

Conclusion

Thus, the therapy with yerba mate solution was capable to reverse abdominal obesity, leptin resistance and hypertriglyceridemia, suggesting an important role of this bioactive component in the management of obesity in this programming model.

Keywords

ObesityProgrammingFat massLeptinIlex paraguariensis

Copyright information

© Springer-Verlag Berlin Heidelberg 2013