Zusammenfassung
Nicht kodierende regulatorische Ribonukleinsäuren (RNAs), wie z. B. microRNAs, lange nicht kodierende RNAs und zirkuläre RNAs, können die Genexpression von Entzündungsmediatoren und somit den Verlauf und das Fortschreiten einer chronisch entzündlichen Erkrankung beeinflussen. Neuere Studien unter Verwendung von Antisense-Oligonukleotiden zeigen, dass sich nicht kodierende regulatorische RNAs als neuartige therapeutische Zielmoleküle für die Behandlung von rheumatisch entzündlichen Erkrankungen eignen.
Abstract
Non-coding regulatory ribonucleic acids (RNA), including microRNA, long non-coding RNA and circular RNA, can influence the expression of genes mediating inflammatory processes and therefore affect the course and progression of chronic inflammatory diseases. Recent studies using antisense oligonucleotides suggest that such non-coding regulatory RNAs are suitable as novel therapeutic target molecules for the treatment of inflammatory rheumatic diseases.
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G.A. Heinz und M.-F. Mashreghi geben an, dass kein Interessenkonflikt besteht.
Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.
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A. Radbruch, Berlin
H. Schulze-Koops, München
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Heinz, G.A., Mashreghi, MF. Rolle nicht kodierender regulatorischer Ribonukleinsäuren bei chronisch entzündlichen Erkrankungen. Z Rheumatol 75, 402–405 (2016). https://doi.org/10.1007/s00393-016-0085-3
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DOI: https://doi.org/10.1007/s00393-016-0085-3