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Evaluation of cardiac autonomic function by various indices in patients with primary premature ovarian failure

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Abstract

Background

The association between premature ovarian failure (POF) and cardiovascular diseases (CVD) was investigated previously, but none of the studies have looked at cardiac autonomic functions in these patients. In this study, we aimed to evaluate cardiac autonomic functions in patients with POF.

Methods

We enrolled 26 female patients (mean age 37.5 ± 10.1 years) with primary POF and 31 healthy subjects (mean age 37.5 ± 9.0 years). All participants underwent 24-h Holter recording. Heart rate recovery (HRR) indices were calculated by subtracting 1st-, 2nd- and 3rd-min heart rates from maximal heart rate. Heart rate variability (HRV) and heart rate turbulence (HRT) parameters were analyzed in all patients.

Results

Both groups were similar with regard to age, gender, body mass index and left ventricular ejection fraction. Mean HRR1 (p = 0.018), HRR2 (p = 0.021) and HRR3 (p = 0.027) values were significantly higher in the control group. When HRV considered SDNN, SDANN, RMSSD, PNN50 and HF were significantly decreased in patients with POF compared to healthy controls, but LF and LF/HF were significantly higher in POF patients. Both HRT onset and slope were more abnormal in POF patients. Also, there was a significant correlation between HRR, HRV and HRT parameters and FSH, LH and estradiol levels.

Conclusion

Our study results suggest that cardiac autonomic function is impaired in patients with POF despite the absence of overt cardiac involvement and symptoms. Further studies are needed to elucidate the prognostic significance and clinical implications of impaired autonomic functions in patients with POF.

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Authors and Affiliations

  1. Develi State Hospital, Kayseri, Turkey

    Hikmet Yorgun

  2. Department of Cardiology, Faculty of Medicine, Hacettepe University, 06100, Sihhiye, Ankara, Turkey

    Kadri Murat Gürses, Uğur Canpolat, Ergün Barış Kaya, Kudret Aytemir, Ali Oto, Giray Kabakçı & Lale Tokgözoğlu

  3. Department of Obstetrics and Gynecology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

    Zuhal Yapıcı & Gürkan Bozdağ

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  1. Hikmet Yorgun
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  2. Kadri Murat Gürses
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Correspondence to Kadri Murat Gürses.

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Yorgun, H., Gürses, K.M., Canpolat, U. et al. Evaluation of cardiac autonomic function by various indices in patients with primary premature ovarian failure. Clin Res Cardiol 101, 753–759 (2012). https://doi.org/10.1007/s00392-012-0455-z

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  • DOI: https://doi.org/10.1007/s00392-012-0455-z

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