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Oncologic outcome of colorectal cancer patients over age 80: a propensity score-matched analysis

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

It remains unclear whether old age is a poor prognostic factor in colorectal cancer (CRC). We compared oncologic outcomes in CRC patients according to age, using 80 as the dividing point.

Methods

CRC patients who underwent radical surgery from 2000 to 2011 were evaluated. We performed matched and adjusted analyses comparing oncologic outcomes between patients with ≥ 80 and < 80 years old.

Results

Among 9562 patients, 222 were elderly. The median age was 82.0 years in elderly patients and 59.0 years in young patients. Elderly patients received less neoadjuvant or adjuvant therapy compared to young patients (p < 0.001). After recurrence, significantly fewer elderly patients received additional treatments (p < 0.001). Before matching, disease-free survival (DFS) and cancer-specific survival (CSS) were significantly lower for elderly patients compared to those for young patients (p < 0.001 and p < 0.001, respectively). After matching, DFS and CCS were not significantly different between the two groups (p = 0.400 and p = 0.267, respectively). In a multivariate analysis for prognostic factors, old age was not an independent poor prognostic factor of DFS and CCS (p = 0.619 and p = 0.137, respectively).

Conclusions

Elderly patients aged ≥ 80 years with CRC had similar oncologic outcome to young patients, and age was not an independent prognostic factor.

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Funding

This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (grant number 2015R1A1A1A05001160).

Author information

Authors and Affiliations

  1. Department of Surgery, College of Medicine, Ewha Womans University, Seoul, South Korea

    Bo Young Oh

  2. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, South Korea

    Jung Wook Huh, Hee Cheol Kim, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun & Woo Yong Lee

  3. Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Ho-Kyung Chun

Authors
  1. Bo Young Oh
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  2. Jung Wook Huh
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Corresponding authors

Correspondence to Jung Wook Huh or Hee Cheol Kim.

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This study was approved by the Samsung Medical Center Institutional Review Board.

Conflict of interest

The authors declare that they have no conflict of interest.

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Oh, B.Y., Huh, J.W., Kim, H.C. et al. Oncologic outcome of colorectal cancer patients over age 80: a propensity score-matched analysis. Int J Colorectal Dis 33, 1011–1018 (2018). https://doi.org/10.1007/s00384-018-3028-4

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  • DOI: https://doi.org/10.1007/s00384-018-3028-4

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