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A comparative evaluation of ablations produced by high-frequency coagulation-, argon plasma coagulation-, and cryotherapy devices in porcine liver

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Abstract

Introduction

Hepatic resection is the only curative treatment option for primary or metastatic malignancies of the liver. Although R1 resections can also lead to prolonged survival, the main surgical goal is complete tumor resection (R0). To achieve this, additional treatment of the resection margin with ablation devices is discussed. Using a porcine in vivo model, we therefore analyzed the effect of different ablation devices on depth and completeness of hepatic parenchymal cell destruction.

Methods

Swabian–Hall strain pigs underwent ablation on the surface of the right, middle, or left liver lobe using seven different types of high-frequency (HF)-, cryotherapy (Cryo)-, or argon plasma coagulation (APC) devices. Penetration depth and volume were analyzed from histological sections. Severity of parenchymal cell destruction was assessed by a histomorphological score.

Results

The greatest penetration depth was achieved with Cryo (10.4 ± 1.7 mm), whereas HF and APC exhibited a smaller penetration depth. However, HF and APC compared to Cryo achieved complete destruction of the intralobular architecture and hepatocellular morphology depending on the application time and the adjusted power.

Conclusion

HF, APC, and Cryo applied to the liver surface induce different parenchymal penetration depth and cell destruction. HF and APC are considered to be standard surgical instruments and therefore recommended as standard treatment, whereas Cryo may be used only if particularly deep penetration is required.

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Acknowledgments

We appreciate the excellent technical assistance of Janine Becker.

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Authors and Affiliations

  1. Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, 66421, Homburg/Saar, Germany

    J. Sperling, C. Ziemann, J. Schuld, M. K. Schilling & O. Kollmar

  2. Institute for Clinical and Experimental Surgery, University of Saarland, 66421, Homburg/Saar, Germany

    M. W. Laschke & M. D. Menger

Authors
  1. J. Sperling
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  2. C. Ziemann
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  3. J. Schuld
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  4. M. W. Laschke
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  5. M. K. Schilling
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  6. M. D. Menger
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  7. O. Kollmar
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Correspondence to J. Sperling.

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Sperling, J., Ziemann, C., Schuld, J. et al. A comparative evaluation of ablations produced by high-frequency coagulation-, argon plasma coagulation-, and cryotherapy devices in porcine liver. Int J Colorectal Dis 27, 1229–1235 (2012). https://doi.org/10.1007/s00384-012-1504-9

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  • DOI: https://doi.org/10.1007/s00384-012-1504-9

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