Influence of postoperative enteral nutrition on cellular immunity. A random double-blinded placebo controlled clinical trial
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The aim of this study was to discover if the cellular immunological response is different in patients receiving early postoperative enteral nutrition compared to patients who only receive “water”.
In a random double-blind prospective trial, 30 patients received Nutridrink® and 30 patients received placebo (water) through a nasoduodenal tube from the day of operation to the fourth postoperative day. Leukocyte differential count was examined preoperatively, and on the first, third, and seventh postoperative days. Subpopulations of lymphocytes were flow cytometrically analysed. IL-1ra and soluble IL-2R were investigated by use of an enzyme-linked immunosorbent assay.
In the enteral nutrition group, a significantly larger number of circulating monocytes and NK-cells and a significantly larger expression of HLA-DR were found. In the nutrition group, a tendency to larger numbers of T-lymphocyte subpopulations was found. No difference in IL-1ra and soluble IL-2R was found between the groups.
Early postoperative enteral nutrition has an important influence on the immediate unspecific cellular immunity and an activating effect on the specific cellular immunity compared to “no food”.
- Bokhorst-de Van Der Schueren, MA, Quak, JJ, Blomberg-van der Flier BM, BM, Kuik, DJ, Langendoen, SI, Snow, GB, Green, CJ, Leeuwen, PA (2001) Effect of perinutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am J Clin Nutr 73: pp. 323-332
- Riso, S, Aluffi, P, Brugnani, M, Farinetti, F, Pia, F, D’Andrea, F (2000) Postoperative enteral immunonutrition in head and neck cancer patients. Clin Nutr 19: pp. 407-412 CrossRef
- Kemen, M, Senkal, M, Homann, HH, Mumme, A, Dauphin, AK, Baier, J, Wndeler, J, Neumann, H, Zumtobel, V (1995) Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet versus placebo in cancer patients. Crit Care Med 23: pp. 652-659 CrossRef
- Senkal, M, Zumtobel, V, Bauer, KH, Marpe, B, Wolfram, G, Frei, A, Eickhoff, U, Kemen, M (1999) Outcome and cost-effectiveness of perioperative enteral immunonutrition in patients undergoing elective upper gastrointestinal tract surgery: a prospective randomized study. Arch Surg 134: pp. 1309-1316 CrossRef
- Braga, M, Gianotti, L, Nespoli, L, Radaelli, G, Carlo, V (2002) Nutritional approach in malnourished surgical patients: a prospective randomized study. Arch Surg 137: pp. 174-180 CrossRef
- Gianotti, L, Braga, M, Fortis, C, Soldini, L, Vignali, A, Clombu, S, Radaeli, G, Carlo, V (1999) A prospective, randomized clinical trial on perioperative feeding with an arginine-, omega-3 fatty acid-, and RNA-enriched enteral diet: effect on host response and nutritional status. JPEN J Parenter Enteral Nutr 23: pp. 314-320 CrossRef
- Lennard, TW, Shenton, BK, Borzotta, A, Donnelly, PK, White, M, Gerrie, LM, Proud, G, Taylor, RM (1985) The influence of surgical operations on components of the human immune system. Br J Surg 72: pp. 771-776 CrossRef
- Haupt, W, Riese, J, Mehler, C, Weber, K, Zowe, M, Hohenberger, W (1998) Monocyte function before and after surgical trauma. Dig Surg 15: pp. 102-104 CrossRef
- McIrvine, AJ, Mannick, JA (1983) Lymphocyte function in the critically ill surgical patient. Surg Clin N Am 63: pp. 245-261
- Beier-Holgersen, R, Boesby, S (1996) Influence of postoperative enteral nutrition on post-surgical infections. Gut 39: pp. 833-835 CrossRef
- Toft, P, Dagnaes-Hansen, F, Tonnesen, E, Petersen, MS (2002) Influence of surgery and endotoxin-induced sepsis combined on natural killer cell activity, oxidative burst of granulocytes and antigen presentation capability of monocytes. Acta Anaesthesiol Scand 46: pp. 405-410 CrossRef
- Beier-Holgersen, R, Brandstrup, B (1999) Influence of early postoperative enteral nutrition versus placebo on cell-mediated immunity, as measured with the multitest® CMI. Scand J Gastroenterol 34: pp. 98-102 CrossRef
- Murakami, S, Sakata, H, Tsuji, Y, Okubo, K, Takahashi, T, Kikuchi, M, Hirayama, R (2003) Changes in the levels of serum-soluble interleukin-2 receptor after surgical stress. Surg Today 33: pp. 565-570 CrossRef
- Maruna, P, Gurlich, R, Frasko, R, Chachkhiani, I, Marunova, M, Owen, K, Peskova, M (2002) Cytokines and soluble cytokine receptors in the perioperative period. Sb Lek 103: pp. 273-282
- Influence of postoperative enteral nutrition on cellular immunity. A random double-blinded placebo controlled clinical trial
International Journal of Colorectal Disease
Volume 27, Issue 4 , pp 513-520
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- Abdominal surgery
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- Cellular immunity
- Natural killer cells
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