Colonoscopy screening for individuals aged 40–49 years with a family history of stomach cancer in Korea
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
For asymptomatic individuals aged 40–49 years, screening for colorectal cancer is recommended only if individuals are at an increased risk. A family history of colon cancer (FHCRC) is considered to increase risk, however, whether family history of stomach cancer (FHSC) increases the risk of adenoma is not well known. We aimed to see whether FHSC increases the risk in asymptomatic individuals aged 40–49 years in Korea.
Among asymptomatic individual aged 40–49 years who underwent colonoscopy screening, risk of adenoma was assessed according to FHCRC or FHSC.
Of 3,160 individuals, male comprised 1,602 individuals (50.7%). FHCRC and FHSC was noticed in 163 (5.2%) and 227 (7.0%) individuals, respectively. Prevalence of adenoma was 31.9 %, 28.8%, and 22.3% for individuals with FHCRC, individuals with FHSC, and individuals without family history of cancer, respectively. FHSC was an independent risk factor for adenoma (odds ratio, 1.38; 95% confidence interval, 1.02–1.87, P = 0.039) in asymptomatic individuals aged 40–49 years. Compared with individuals with FHCRC, individuals with FHSC showed no difference in risk for adenoma (P = 0.347).
As with individuals with FHCRC, individuals with FHSC might need to be considered as an individual with increased risk for adenoma. Therefore, earlier screening might be needed for asymptomatic individuals aged 40–49 years with FHSC in Korea.
- Bazzoli F, Fossi S, Sottili S et al (1995) The risk of adenomatous polyps in asymptomatic first-degree relatives of persons with colon cancer. Gastroenterology 109:783–788 CrossRef
- Fernandez E, La Vecchia C, D’Avanzo B et al (1997) Risk factors for colorectal cancer in subjects with family history of the disease. Br J Cancer 75:1381–1384
- Kerber RA, Slattery ML, Potter JD et al (1998) Risk of colon cancer associated with a family history of cancer or colorectal polyps: the diet, activity, and reproduction in colon cancer study. Int J Cancer 78:157–160 CrossRef
- St John DJ, McDermott FT, Hopper JL et al (1993) Cancer risk in relatives of patients with common colorectal cancer. Ann Intern Med 118:785–790
- Levin B, Lieberman DA, McFarland B et al (2008) Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. CA Cancer J Clin 58:130–160 CrossRef
- Rafter J, Glinghammar B (1998) Interactions between the environment and genes in the colon. Eur J Cancer Prev 7(Suppl 2):S69–S74 CrossRef
- Lichtenstein P, Holm NV, Verkasalo PK et al (2000) Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 343:78–85 CrossRef
- Park JG, Park YJ, Wijnen JT et al (1999) Gene–environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing. Int J Cancer 82:516–519 CrossRef
- Shin MH, Oh HK, Ahn YO (2008) Ten year trend of cancer incidence in Seoul, Korea: 1993–2002. J Prev Med Public Health 41:92–99 CrossRef
- Lieberman DA, Weiss DG, Bond JH et al (2000) Use of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans Affairs Cooperative Study Group 380. N Engl J Med 343:162–168 CrossRef
- Boutron MC, Faivre J, Quipourt V et al (1995) Family history of colorectal tumours and implications for the adenoma–carcinoma sequence: a case control study. Gut 37:830–834 CrossRef
- Winawer S, Fletcher R, Rex D et al (2003) Colorectal cancer screening and surveillance: clinical guidelines and rationale—update based on new evidence. Gastroenterology 124:544–560 CrossRef
- Fossi S, Bazzoli F, Ricciardiello L et al (2001) Incidence and recurrence rates of colorectal adenomas in first-degree asymptomatic relatives of patients with colon cancer. Am J Gastroenterol 96:1601–1604 CrossRef
- Almendingen K, Hofstad B, Vatn MH (2003) Does a family history of cancer increase the risk of occurrence, growth, and recurrence of colorectal adenomas? Gut 52:747–751 CrossRef
- Regula J, Rupinski M, Kraszewska E et al (2006) Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia. N Engl J Med 355:1863–1872 CrossRef
- Imperiale TF, Wagner DR, Lin CY et al (2000) Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med 343:169–174 CrossRef
- Kim SE, Shim KN, Jung SA et al (2007) An association between obesity and the prevalence of colonic adenoma according to age and gender. J Gastroenterol 42:616–623 CrossRef
- Rundle AG, Lebwohl B, Vogel R et al (2008) Colonoscopic screening in average-risk individuals ages 40 to 49 vs 50 to 59 years. Gastroenterology 134:1311–1315 CrossRef
- Kim JH, Lim YJ, Kim YH et al (2007) Is metabolic syndrome a risk factor for colorectal adenoma? Cancer Epidemiol Biomarkers Prev 16:1543–1546 CrossRef
- Colonoscopy screening for individuals aged 40–49 years with a family history of stomach cancer in Korea
International Journal of Colorectal Disease
Volume 25, Issue 4 , pp 443-447
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Family history of stomach cancer
- Industry Sectors
- Author Affiliations
- 1. Department of Gastroenterology, Daehang Hospital, Seoul, South Korea
- 3. Department of Surgery, Daehang Hospital, Seoul, South Korea
- 2. Department of Pathology, Daehang Hospital, Seoul, South Korea