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Hepatectomy for liver metastasis of colorectal cancer

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Objective

The objective of this study was to investigate whether hepatic resection (HR) can increase the survival of liver metastasis of colorectal cancer (CRC).

Materials and methods

CRC patients (n = 669) with liver metastasis treated at the Zhongshan Hospital, Fudan University from 1/2000 to 7/2007 were included in the study to investigate the relationship between HR and cancer survival.

Results

CRC patients (n = 669) with liver metastases who had primary tumor resection were grouped in synchronous liver metastasis (SLM; 56.7%, n = 379) and metachronous liver metastasis (MLM) groups (43.3%, n = 290). Hepatic resection rates were lower (32.5%, n = 123) in the SLM than the MLM group (44.8%, n = 130, P < 0.05). The 30-day mortality rate in the MLM (2.3%) was significantly lower than SLM (2.4%) groups. The 5-year survival rates (36.6%) was same compared to SLM group (33.1%, P > 0.05). One-, 2-, and 3-year survival of stages I and II operation cases were 92.5% vs 86.5%, 0.7% vs 58.0%, and 42.1% vs 44.9% (P > 0.05) in the SLM group, respectively. Recurrence after first hepatic resection associated with a 2.23-fold increased risk of death (P < 0.01). Incision margins larger than 1 cm and HR for recurrence associated with 34% and 27% (P < 0.05) decreased death risk.

Conclusions

Hepatic resection could help the survival of liver metastasis of colorectal cancer, and stage I surgery is safe for this disease.

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Authors and Affiliations

  1. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China

    Jianmin Xu, Ye Wei, Yunshi Zhong, Li Ren & Xinyu Qin

  2. Colorectal Cancer Research Center, Fudan University, Shanghai, People’s Republic of China

    Jianmin Xu, Ye Wei, Yunshi Zhong, Li Ren & Xinyu Qin

  3. Department of Surgery, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China

    Jianmin Xu, Ye Wei, Yunshi Zhong, Li Ren & Xinyu Qin

  4. Department of Hepatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China

    Jia Fan, Jian Zhou & Lunxiu Qin

Authors
  1. Jianmin Xu
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  2. Ye Wei
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  3. Yunshi Zhong
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  4. Jia Fan
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  5. Jian Zhou
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  6. Lunxiu Qin
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  7. Li Ren
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  8. Xinyu Qin
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Corresponding author

Correspondence to Jianmin Xu.

Additional information

Xu Jianmin, Wei Ye, and Zhong Yunshi contributed equally to this paper.

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Xu, J., Wei, Y., Zhong, Y. et al. Hepatectomy for liver metastasis of colorectal cancer. Int J Colorectal Dis 24, 419–425 (2009). https://doi.org/10.1007/s00384-008-0619-5

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  • DOI: https://doi.org/10.1007/s00384-008-0619-5

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