Abstract
Purpose
Epididymal anomalies are common in cryptorchid patients. This led us to consider that anomalies of the epididymis, to which the gubernaculum is attached, or abnormal attachment of the cranial end of the gubernaculum, could lead to cryptorchidism.
Methods
Twenty-eight male Sprague–Dawley rats were divided into two groups: In Group 1 rats (n = 14), the epididymis was isolated from the testis, and in Group 2 rats (n = 14), the gubernaculum was isolated from the epididymis and re-attached to the tail of the epididymis. In both groups, the non-operated testes were used as the control.
Results
In Group 1, cryptorchidism rates were 1/14 in the control testes and 8/14 in the operated testes (p < 0.01). In Group 2, cryptorchidism rates were 0/13 in the control testes and 6/13 in the operated testes (p < 0.01).
Conclusion
Cryptorchidism was seen when the epididymis was loosely or non-connected to the testis and the gubernaculum was attached solely to the epididymis (mimicking anomalies of ductal fusion) and when the gubernaculum was attached to the tail of the epididymis (mimicking anomalies of ductal suspension). Therefore epididymal anomalies and abnormal attachment of the gubernaculum may play a role in the undescendence of the testes in the rats.
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References
Hutson JM (2013) Journal of Pediatric Surgery-Sponsored Fred McLoed Lecture. Undescended testis: the underlying mechanisms and the effects on germ cells that cause infertility and cancer. J Pediatr Surg 48(5):903–908
Nation TR, Buraundi S, Farmer PJ, Balic A, Newgreen D, Southwell BR, Hutson JM (2011) Development of the gubernaculum during testicular descent in the rat. Anat Rec (Hoboken) 294(7):1249–1260. doi:10.1002/ar.21393
Virtanen HE, Toppari J (2008) Epidemiology and pathogenesis of cryptorchidism. Hum Reprod Update 14(1):49–58
Toppari J, Rodprasert W, Virtanen HE (2014) Cryptorchidism-disease or symptom? Ann Endocrinol (Paris) 75(2):72–76. doi:10.1016/j.ando.2014.04.010
Gill B, Kogan SJ, Starr S, Reda E, Levitt S (1989) Significance of epididymal and ductal anomalies associated with testicular maldescent. J Urol 142:556–558
Mollaeian M, Mehrabi V, Elahi B (1994) Significance of epididymal and ductal anomalies associated with undescended testis: study in 652 cases. Pediatr Urol 43(6):857–860
Mininberg DT, Schlossberg S (1983) The role of the epididymis in testicular descent. J Urol 129(6):1207–1208
Marshall FF, Shermeta DW (1979) Epididymal abnormalities associated with undescended testis. J Urol 121:341–343
Koff WJ, Scaletsky R (1990) Malformations of the epididymis in undescended testis. J Urol 143:340–343
Heath AL, Man WK, Eckstein HB (1984) Epididymal abnormalities associated with maldescent of the testis. J Pediatr Surg 19(1):47–49
Kuçukaydin M, Ozokutan BH, Turan C, Okur H, Köse O (1998) Malformation of the epididymis in undescended testis. Pediatr Surg Int 14(3):189–191
Favorito LA, Sampaio FJB, Javaroni V, Cardoso LEM, Costa WS (2000) Proximal insertion of gubernaculum testis in normal human fetuses and in boys with cryptorchidism. J Urol 164:792–794
Favorito LA, Costa WS, Sampaio FJB (2006) Analysis of anomalies of the epididymis and processus vaginalis in human fetuses and in patients with cryptorchidism treated and untreated with human chorionic gonadotrophin. BJU Int 98:854–857
Karahan S (2009) Fötal ve neonatal hayvan modellerinin özellikleri. In: Çakmak AM, Karagüzel G, Soyer T, Günaydın S, Karahan S (eds) Çocuk Cerrahisinde Deneysel Araştırmalar, 1st edn. Çocuk Cerrahisi Derneği, Özkan Matbaacılık, Ankara, pp 35–38
Fiegel HC, Rolle U, Metzger R, Gfroerer S, Kluth D (2011) Embryology of the testicular descent. Semin Pediatr Surg 20(3):170–175
Acer T (2012) Epididim anomalileri ile inmemiş testis arasındaki ilişki nedir? Ender bir olgu, yeni bir tedavi yöntemi ve literatür incelemesi. Çocuk Cerrahisi Dergisi 26(1–2):84–88
Abe T, Aoyama K, Gotoh T, Akiyama T, Iwamura Y, Kumori K (1996) Cranial attachment of the gubernaculum associated with undescended testis. J Pediatr Surg 31(5):652–655
Hutson JM, Balic A, Nation T, Southwell B (2010) Cryptorchidism. Semin Pediatr Surg 19(3):215–224
Acknowledgement
We thank Mustafa Agah Tekindal for his help with the statistical analysis.
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Acer, T., Hiçsönmez, A. The separation of the epididymis and the abnormal attachment of the gubernaculum cause undescendence in the rat testes. Pediatr Surg Int 30, 1155–1161 (2014). https://doi.org/10.1007/s00383-014-3596-5
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DOI: https://doi.org/10.1007/s00383-014-3596-5