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Advanced MR imaging in hemispheric low-grade gliomas before surgery; the indications and limits in the pediatric age

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Abstract

Introduction

Advanced magnetic resonance imaging (MRI) techniques is an umbrella term that includes diffusion (DWI) and diffusion tensor (DTI), perfusion (PWI), spectroscopy (MRS), and functional (fMRI) imaging. These advanced modalities have improved the imaging of brain tumors and provided valuable additional information for treatment planning. Despite abundant literature on advanced MRI techniques in adult brain tumors, few reports exist for pediatric brain ones, potentially because of technical challenges.

Review of the literature

The authors review techniques and clinical applications of DWI, PWI, MRS, and fMRI, in the setting of pediatric hemispheric low-grade gliomas.

Personal experience

The authors propose their personal experience to highlight benefits and limits of advanced MR imaging in diagnosis, grading, and presurgical planning of pediatric hemispheric low-grade gliomas.

Discussion

Advanced techniques should be used as complementary tools to conventional MRI, and in theory, the combined use of the three techniques should ensure achieving the best results in the diagnosis of hemispheric low-grade glioma and in presurgical planning to maximize tumor resection and preserve brain function.

Future perspectives

In the setting of pediatric neurooncology, these techniques can be used to distinguish low-grade from high-grade tumor. However, these methods have to be applied on a large scale to understand their real potential and clinical relapse, and further technical development is required to reduce the excessive scan times and other technical limitations.

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Authors and Affiliations

  1. Institute of Radiology, Fondazione Policlinico Universitario Agostino Gemelli, Largo A. Gemelli, 1, 00168, Rome, Italy

    Simona Gaudino, Rosellina Russo, Tommaso Verdolotti & Cesare Colosimo

  2. Department of Neuroscience, Imaging and Clinical Science, University “G. D’annunzio”, Chieti, Italy

    Massimo Caulo

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  1. Simona Gaudino
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  2. Rosellina Russo
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  3. Tommaso Verdolotti
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  4. Massimo Caulo
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  5. Cesare Colosimo
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Correspondence to Simona Gaudino.

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Gaudino, S., Russo, R., Verdolotti, T. et al. Advanced MR imaging in hemispheric low-grade gliomas before surgery; the indications and limits in the pediatric age. Childs Nerv Syst 32, 1813–1822 (2016). https://doi.org/10.1007/s00381-016-3142-y

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  • DOI: https://doi.org/10.1007/s00381-016-3142-y

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