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Network-based gene expression analysis of vascular wall of juvenile Moyamoya disease

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Abstract

Subjects

Little is known about the pathology and pathogenesis of the Moyamoya disease (MMD). To better understand the molecular processes involved in MMD gene expression analysis of Moyamoya artery tissue to a control artery, this study was conducted.

Methods

Tissue samples of two MMD and two non-MMD were profiled using oligonucleotide microarrays. Gene ontology classification of the differentially expressed genes was analyzed, and regulatory functional networks and pathways were identified with a network-based computational pathway analysis tool. Analysis of MMD and control tissue revealed 104 differentially expressed genes.

Results

The two major significantly associated gene ontology terms was cellular development and cellular movement. Further network-based analysis showed significant interaction between RNF213 downstream gene networks and the top 3 score gene networks of MMD. Three major nodes of this network were evident in the merged network and were showing interactions with downstream network of RNF213.

Conclusions

Our results demonstrate that cellular development and cellular movement in MMD are the key role of mechanisms.

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Acknowledgments

The authors would like to thank David Huang and staff of the Department of Neurosurgery, Tokyo Women’s Medical University for their guidance in preparing this paper.

Declaration of funding source

This study was supported by research funds of the Department of Neurosurgery, Tokyo Women’s Medical University.

Conflict of interest

The authors have no personal financial or institutional interest in any of the materials or devices described in this article.

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Authors and Affiliations

  1. Department of Neurosurgery, Tokyo Women’s Medical University, 8-1 Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan

    Nobuya Okami, Yasuo Aihara, Hiroyuki Akagawa, Koji Yamaguchi, Akitsugu Kawashima & Yoshikazu Okada

  2. Institute for Integrated Medical Sciences, Tokyo Women’s Medical University, Tokyo, Japan

    Toshiyuki Yamamoto

Authors
  1. Nobuya Okami
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  2. Yasuo Aihara
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  3. Hiroyuki Akagawa
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  4. Koji Yamaguchi
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  5. Akitsugu Kawashima
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  6. Toshiyuki Yamamoto
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  7. Yoshikazu Okada
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Corresponding author

Correspondence to Yasuo Aihara.

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Okami, N., Aihara, Y., Akagawa, H. et al. Network-based gene expression analysis of vascular wall of juvenile Moyamoya disease. Childs Nerv Syst 31, 399–404 (2015). https://doi.org/10.1007/s00381-014-2605-2

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  • DOI: https://doi.org/10.1007/s00381-014-2605-2

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