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Birth prevalence of neural tube defects: a population-based study in South-Eastern Hungary

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Abstract

Purpose

Primary prevention by periconceptional folic acid supplementation can significantly reduce the risk of neural tube defects. EUROCAT, the European network of population-based registries for the epidemiologic surveillance of congenital anomalies, lacks sufficient data on the birth prevalence of neural tube defects in Hungary before and after the promotion of primary prevention by folic acid. Our aims were to compare the birth prevalence of neural tube defects (myelomeningocele, anencephaly and encephalocele) over two 12-year periods in South-Eastern Hungary. Further aims were to compare our data to those ones in other areas in Europe.

Methods

Data were collected from the databases of the Department of Hungarian Congenital Abnormality Registry. The total and live birth prevalence rate of neural tube defects were calculated and compared over 1980–1991 and 1994–2005. In addition, the trends in the total birth prevalence, the number of live births and terminations for and stillbirths with neural tube defects were analysed throughout the period of 1994–2005.

Results

A significant decline was found in the total and live birth prevalence of myelomeningocele, anencephaly and encephalocele over 1994–2005 compared to the period of 1980–1991. The total birth prevalence of neural tube defects, however, showed a trend of increase after 1994, with declining number of live births and increasing number of terminations for neural tube defects.

Conclusion

Public health measures are warranted in order to replace termination of pregnancy with primary prevention in South-Eastern Hungary.

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References

  1. Aicardi J (2009) Malformations of the central nervous system. In: Diseases of the nervous system in childhood, 3rd edn. Mac Keith, London, pp 41–102

    Google Scholar 

  2. Au KS, Ashley-Koch A, Nothrup H (2010) Epidemiologic and genetic aspects of spina bifida and other neural tube defects. Dev Disabil Res Rev 16:6–15

    Article  PubMed  Google Scholar 

  3. Bognár M, Ponyi A, Hauser P, Müller J, Constantin T, Jakab ZS, Schuler D, Garami M (2008) Improper supplementation habits of folic acid intake by Hungarian pregnant women: improper recommendations. J Am Coll Nutr 27:499–504

    PubMed  Google Scholar 

  4. Boltshauser E, Schneider J, Kollias S, Waibel P, Weissert M (2002) Vanishing cerebellum in myelomeningocele. Eur J Paediatr Neurol 6:109–113

    Article  PubMed  Google Scholar 

  5. Boulet SL, Yang Q, Mai C, Kirby RS, Collins JS, Robbins JM, Meyer R, Canfield MA, Mulinare J, National Birth Defects Prevention Network (2008) Trends in the postfortification prevalence of spina bifida and anencephaly in the United States. Birth Defects Res A Clin Mol Teratol 82:527–532

    Article  PubMed  CAS  Google Scholar 

  6. Czeizel AE (2009) Periconceptional folic acid and multivitamin supplementation for the prevention of neural tube defects and other congenital abnormalities. Birth Defects Res A Clin Mol Teratol 85:260–268

    Article  PubMed  CAS  Google Scholar 

  7. Czeizel AE, Dudás I (1992) Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation. N Engl J Med 327:1832–1835

    Article  PubMed  CAS  Google Scholar 

  8. De Wals P, Tairou F, Van Allen MI, Uh SH, Lowry RB, Sibbald B, Evans JA, Van den Hof MC, Zimmer P, Crowley M, Fernandez B, Lee NS, Niyonsenga T (2007) Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med 357:135–142

    Article  PubMed  Google Scholar 

  9. Dolk H, Loane M, Garne E (2010) The prevalence of congenital anomalies in Europe. Adv Exp Med Biol 686:349–364

    Article  PubMed  Google Scholar 

  10. EUROCAT (1974) European Surveillance of Congenital Anomalies (EUROCAT). http://www.eurocat-network.eu/

  11. EUROCAT (2009) EUROCAT Special Report: Prevention of neural tube defects by periconceptional folic acid supplementation in Europe. EUROCAT Central Registry, University of Ulster http://www.eurocat-network.eu/

  12. Frey L, Hauser WA (2003) Epidemiology of neural tube defects. Epilepsia 44(suppl3):4–13

    Article  PubMed  Google Scholar 

  13. Heseker HB, Mason JB, Selhub J, Rosenberg IH, Jacques PF (2009) Not all cases of neural-tube defects can be prevented by increasing the intake of folic acid. Br J Nutr 102:173–180

    Article  PubMed  CAS  Google Scholar 

  14. Juranek J, Salman MS (2010) Anomalous development of brain structure and function in spina bifida myelomeningocele. Dev Disabil Res Rev 16:23–30

    Article  PubMed  Google Scholar 

  15. Mitchell LE (2005) Epidemiology of neural tube defects. Am J Med Genet C Semin Med Genet 135C:88–94

    Article  PubMed  Google Scholar 

  16. MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338:131–137

    Article  Google Scholar 

  17. Ramakrishnan U, Grant F, Goldenberg T, Zongrone A, Martorell R (2012) Effect of women’s nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. Paediatr Perinat Epidemiol 26(suppl1):285–301

    Article  PubMed  Google Scholar 

  18. Rankin J, Glinianaia S, Brown R, Renwick M (2000) The changing prevalence of neural tube defects: a population-based study in the North of England, 1984–96. Northern Congenital Abnormality Survey Steering Group. Paediatr Perinat Epidemiol 14:104–110

    Article  PubMed  CAS  Google Scholar 

  19. Rowland CA, Correa A, Cragan JD, Alverson CJ (2006) Are encephaloceles neural tube defects? Pediatrics 118:916–923

    Article  PubMed  Google Scholar 

  20. Sandor J (2007) Report on periconceptional folic acid supplementation for Hungary. http://www.eurocat-network.eu/content/NTD-Dec2007-Hungary.pdf

  21. Srour M, Rioux MF, Varga C, Lortie A, Major P, Robitaille Y, Décarie JC, Michaud J, Carmant L (2011) The clinical spectrum of nodular heterotopias in children: report of 31 patients. Epilepsia 52:728–737

    Article  PubMed  Google Scholar 

  22. Stoll C, Dott B, Alembik Y, Roth MP (2011) Associated malformations among infants with neural tube defects. Am J Med Genet A 155:565–568

    Article  Google Scholar 

  23. Vinck A, Nijhuis-van der Sanden MWG, Roeleveld NJA, Mullaart RA, Rotteveel JJ, Maassen BAM (2010) Motor profile and cognitive functioning in children with spina bifida. Eur J Paediatr Neurol 14:86–92

    Article  PubMed  Google Scholar 

  24. Yi Y, Lindemann M, Colligs A, Snowball C (2011) Economic burden of neural tube defects and impact of prevention with folic acid: a literature review. Eur J Pediatr 170:1391–1400

    Article  PubMed  Google Scholar 

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Acknowledgments

Dr László Sztriha has been funded by a Marie Curie International Reintegration Grant (MIRG-CT-2005-030967) within the 6th European Community Framework Programme.

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Authors and Affiliations

  1. Department of Paediatrics, Faculty of Medicine, University of Szeged, Temesvári krt 35-37, 6726, Szeged, Hungary

    Nóra Szabó, Gyurgyinka Gergev & László Sztriha

  2. Department of Hungarian Congenital Abnormality Registry and Surveillance, National Centre for Healthcare Audit and Inspection, Budapest, Hungary

    Andrea Valek

  3. Department of Medical Physics and Informatics, Faculty of Medicine, University of Szeged, Szeged, Hungary

    József Eller

  4. Department of Pathology, Faculty of Medicine, University of Szeged, Szeged, Hungary

    László Kaizer

Authors
  1. Nóra Szabó
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  2. Gyurgyinka Gergev
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  3. Andrea Valek
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  4. József Eller
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  5. László Kaizer
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  6. László Sztriha
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Correspondence to László Sztriha.

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Szabó, N., Gergev, G., Valek, A. et al. Birth prevalence of neural tube defects: a population-based study in South-Eastern Hungary. Childs Nerv Syst 29, 621–627 (2013). https://doi.org/10.1007/s00381-012-1951-1

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  • DOI: https://doi.org/10.1007/s00381-012-1951-1

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