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Polymicrogyria: correlation of magnetic resonance imaging and clinical findings

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Abstract

Aim

The aim of this study is to evaluate the correlation between clinical presentation and the extent of cortical involvement in patients with polymicrogyria.

Materials and methods

The magnetic resonance imaging findings of 26 patients were evaluated for the location and distribution of polymicrogyria. Presence of asphyxia at birth and serological tests for TORCH infections, the presence and type (spastic, flaccid) of motor deficits, mental development, microcephaly, and epilepsy were noted.

Results

Nineteen patients had bilateral, whereas seven had unilateral involvement. Patients with unilateral polymicrogyria presented later with milder symptoms. The most encountered symptom in patients with bilateral involvement was mental motor retardation (MMR) (89%) and speech problems (84%). The clinical presentations of patients with asphyxia and positive serological tests for cytomegalovirus (CMV) were worse. All patients with positive serological tests for CMV had bilateral involvement. The perisylvian region was affected in five (71%) patients with unilateral involvement. The most encountered presenting symptom in these patients was epilepsy. Cerebral palsy was seen in three (43%) of the patients, and all of them had left hemiparesis. Microcephaly, MMR, and speech delay were detected in one (14%) of the patients.

Conclusions

Late presenting epilepsy may be a predictor of a unilateral polymicrogyria and is associated with relatively good prognosis. CMV infection and the presence of asphyxia are predictors of worse prognosis.

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Authors and Affiliations

  1. Department of Radiology, Faculty of Medicine, Erciyes University, 38039 Melikgazi, Kayseri, Turkey

    Ertugrul Mavili, Abdulhakim Coskun, Halil Donmez & Ali Yikilmaz

  2. Department of Pediatrics, Faculty of Medicine, Division of Pediatric Neurology, Erciyes University, Kayseri, Turkey

    Huseyin Per & Sefer Kumandas

Authors
  1. Ertugrul Mavili
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  2. Abdulhakim Coskun
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  3. Huseyin Per
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  4. Halil Donmez
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  5. Sefer Kumandas
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  6. Ali Yikilmaz
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Correspondence to Ertugrul Mavili.

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Mavili, E., Coskun, A., Per, H. et al. Polymicrogyria: correlation of magnetic resonance imaging and clinical findings. Childs Nerv Syst 28, 905–909 (2012). https://doi.org/10.1007/s00381-012-1703-2

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  • DOI: https://doi.org/10.1007/s00381-012-1703-2

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