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Chemical priming for spinal cord injury: a review of the literature part II—potential therapeutics

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Abstract

Introduction

Spinal cord injury is a complex cascade of reactions secondary to the initial mechanical trauma that puts into action the innate properties of the injured cells, the circulatory, inflammatory, and chemical status around them, into a non-permissive and destructive environment for neuronal function and regeneration. Priming means putting a cell, in a state of “arousal” towards better function. Priming can be mechanical as trauma is known to enhance activity in cells.

Materials and methods

A comprehensive review of the literature was performed to better understand the possible chemical primers used for spinal cord injuries.

Conclusions

Taken together, many studies have shown various promising results using the substances outlined herein for treating SCI.

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Authors and Affiliations

  1. Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AR, USA

    Martin M. Mortazavi & Nicholas Theodore

  2. Pediatric Neurosurgery, Children’s Hospital, 1600 7th Avenue South ACC 400, Birmingham, AL, 35233, USA

    Ketan Verma, Aman Deep, Fatemeh B. Esfahani & R. Shane Tubbs

  3. Division of Neurosurgery, Birmingham, AL, USA

    Patrick R. Pritchard

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  1. Martin M. Mortazavi
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  2. Ketan Verma
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Correspondence to R. Shane Tubbs.

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Mortazavi, M.M., Verma, K., Deep, A. et al. Chemical priming for spinal cord injury: a review of the literature part II—potential therapeutics. Childs Nerv Syst 27, 1307–1316 (2011). https://doi.org/10.1007/s00381-010-1365-x

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