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Relationships of left ventricular strain and strain rate to wall stress and their afterload dependency

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Abstract

Whether and how left ventricular (LV) strain and strain rate correlate with wall stress is not known. Furthermore, it is not determined whether strain or strain rate is less dependent on the afterload. In 41 healthy young adults, LV global peak strain and systolic peak strain rate in the longitudinal direction (LS and LSR, respectively) and circumferential direction (CS and CSR, respectively) were measured layer-specifically using speckle tracking echocardiography (STE) before and during a handgrip exercise. Among all the points before and during the exercise, all the STE parameters significantly correlated linearly with wall stress (LS: r = −0.53, p < 0.01, LSR: r = −0.28, p < 0.05, CS in the inner layer: r = −0.72, p < 0.01, CSR in the inner layer: r = −0.47, p < 0.01). Strain more strongly correlated with wall stress than strain rate (r = −0.53 for LS vs. r = −0.28 for LSR, p < 0.05; r = −0.72 for CS vs. r = −0.47 for CSR in the inner layer, p < 0.05), whereas the interobserver variability was similar between strain and strain rate (longitudinal 6.2 vs. 5.2 %, inner circumferential 4.8 vs. 4.7 %, mid-circumferential 7.9 vs. 6.9 %, outer circumferential 10.4 vs. 9.7 %), indicating that the differences in correlation coefficients reflect those in afterload dependency. It was thus concluded that LV strain and strain rate linearly and inversely correlated with wall stress in the longitudinal and circumferential directions, and strain more strongly depended on afterload than did strain rate. Myocardial shortening should be evaluated based on the relationships between these parameters and wall stress.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, Japan

    Daisuke Murai, Satoshi Yamada, Taichi Hayashi, Hiroyuki Iwano & Hiroyuki Tsutsui

  2. Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

    Kazunori Okada, Sanae Kaga & Taisei Mikami

  3. Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan

    Hisao Nishino, Masahiro Nakabachi, Shinobu Yokoyama, Ayumu Abe & Ayako Ichikawa

  4. Clinical Research and Medical Innovation Center, Hokkaido University Hospital, Sapporo, Japan

    Kota Ono

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  1. Daisuke Murai
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  2. Satoshi Yamada
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Correspondence to Satoshi Yamada.

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Murai, D., Yamada, S., Hayashi, T. et al. Relationships of left ventricular strain and strain rate to wall stress and their afterload dependency. Heart Vessels 32, 574–583 (2017). https://doi.org/10.1007/s00380-016-0900-4

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  • DOI: https://doi.org/10.1007/s00380-016-0900-4

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