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Impact of gender difference on long-term outcomes of percutaneous coronary intervention for coronary artery disease in patients under statin treatment

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Abstract

The incidence of adverse outcomes after percutaneous coronary intervention (PCI) is higher in women than in men. Statins reduce the likelihood of cardiovascular events arising in patients with coronary artery disease (CAD), but the impact of gender difference on long-term outcomes of PCI for CAD under statin treatment has not been established. We prospectively enrolled 3,580 consecutive patients with CAD who were treated by PCI at our institution between 2000 and 2011. Among these, 2,009 (43.9 %; male, n = 1619; female, n = 390) were under statin therapy at the time of PCI. We evaluated the incidence of major adverse cardiac events (MACE) including all-cause death and acute coronary syndrome (ACS). Age was significantly more advanced and the prevalences of hypertension and chronic kidney disease were higher among the female, than the male patients. Low-density lipoprotein cholesterol levels were significantly higher in women than in men (111.5 ± 38.9 vs. 107.5 ± 3 3.9 mg/dL, p = 0.04). During a median follow-up period of 6.3 years, MACE that occurred in 336 (16.7 %) patients included 206 (10.2 %) with all-cause death and 154 (7.7 %) with ACS. The cumulative rate of MACE tended to be higher in women than in men but the difference did not reach significance (19.7 vs. 16.0 %; p = 0.08, log-rank test). Multivariable Cox regression analysis showed that being female was not associated with MACE after adjusting for age (HR 1.22; 95 % CI 0.94–1.57; p = 0.13) and other variables (HR 1.14; 95 % CI 0.86–1.49; p = 0.35). Long-term clinical outcomes were comparable between male and female patients with coronary artery disease who were administered with statins and underwent PCI even though the baseline characteristics were worse among the females.

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Acknowledgments

The authors thank the staff of the Department of Cardiovascular Medicine at Juntendo University and the Department of Cardiology at Juntendo University Shizuoka Hospital. We also appreciate the secretarial assistance of Yumi Nozawa and Ayako Onodera.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Hideki Wada, Katsumi Miyauchi, Hirohisa Endo, Shinichiro Doi, Ryo Naito, Tomotaka Dohi, Takatoshi Kasai, Hiroshi Tamura, Shinya Okazaki, Kikuo Isoda & Hiroyuki Daida

  2. Department of Cardiovascular Medicine, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka, 410-2295, Japan

    Manabu Ogita, Jun Shitara, Hirokazu Konishi, Shuta Tsuboi & Satoru Suwa

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  1. Hideki Wada
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Correspondence to Manabu Ogita.

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Conflict of interest

HD. has received speakers’ Bureau/Honoraria from MSD, AstraZeneca, Kowa Pharmaceutical, Sanofi-Aventis, GlaxoSmithKline, Shionogi, Daiichi-Sankyo, Takeda Pharmaceutical, Mitsubishi Tanabe Pharma, Pfizer and Astellas Pharma and research funds from Takeda Pharmaceutical, Bristol-Myers Squibb, Nippon Boehringer Ingelheim, Astellas Pharma, Novartis Pharma, MSD, Sanofi-Aventis, Otsuka Pharmaceutical, Dainippon Sumitomo Pharma, Pfizer, Kowa Pharmaceutical, Shionogi, AstraZeneca, Teijin and Morinaga Milk Industry. K. M. has received speakers’ Bureau/Honoraria from MSD, AstraZeneca, Kowa Pharmaceutical, Sanofi-Aventis, Shionogi, Daiichi-Sankyo, Takeda Pharmaceutical, Pfizer, Astellas Pharma and Novartis Pharma. The other authors reported that they have no conflict of interests.

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Wada, H., Ogita, M., Miyauchi, K. et al. Impact of gender difference on long-term outcomes of percutaneous coronary intervention for coronary artery disease in patients under statin treatment. Heart Vessels 32, 16–21 (2017). https://doi.org/10.1007/s00380-016-0835-9

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