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Prevalence of the human papillomavirus (HPV) expression of the inner prepuce in asymptomatic boys and men

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Abstract

Objective

To investigate the prevalence of high-risk (HR) and low-risk (LR) human papillomavirus (HPV) in prepuces of boys and men without any HPV related lesions.

Patients and methods

Between 2009 and 2011, a total collective of 250 boys and men were investigated in this prospective study. The samples were subdivided into 3 groups regarding their age, consisting of 125 (50 %) children (0–10 years), 38 (15.2 %) adolescents (11–20 years) and 87 (34.8 %) adults (>20 years). In situ hybridization (ISH) was performed to detect HR and LR virus types within the epithelium, followed by microscopic interpretation and determination between episomal and integrative signal pattern.

Results

Our results revealed high levels of HPV concentration (HR and LR) in all age groups: HR versus LR positivity was seen in 45.5 versus 35 % (children), 60.6 versus 63.6 % (adolescents) and 58.3 versus 48.6 % (adults). The topmost rate of HR (59.8 %)- and LR (50.6 %)-positive probes was found in the group with high estimated sexual activity (>14 years).

Conclusion

Concerning the high prevalence of male HPV infection even in children, indicating non-sexual transmission pathways, inclusion of boys in the vaccination program seems to be required reducing their burden of HPV related disease.

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Acknowledgments

We want to thank Gabriel Djedovic, Erich Brenner, Elisabeth Richter, Irma Sottsas, Linda Lovdok and Stefan Reininghaus for their support and their contribution to this work.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Urology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria

    Gerald Klinglmair, Renate Pichler, Wolfgang Horninger & Josef Oswald

  2. Department of Pathology, Medical University of Innsbruck, Innsbruck, Austria

    Bettina Zelger

  3. Department of Urology, Faculty of Medicine, Uludag University, 16059, Gorukle, Bursa, Turkey

    Hasan Serkan Dogan

  4. Department of Pediatric Urology, St. Vincent’s Hospital, Linz, Austria

    Tanja Becker & Markus Riccabona

  5. Department of Urology, St. Vincent’s Hospital, Linz, Austria

    Johannes Esterbauer & Wolfgang Loidl

Authors
  1. Gerald Klinglmair
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  2. Renate Pichler
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  3. Bettina Zelger
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  4. Hasan Serkan Dogan
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  5. Tanja Becker
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  6. Johannes Esterbauer
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  7. Markus Riccabona
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  8. Wolfgang Loidl
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  9. Wolfgang Horninger
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  10. Josef Oswald
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Corresponding author

Correspondence to Josef Oswald.

Additional information

Gerald Klinglmair and Renate Pichler contributed equally to this study.

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Klinglmair, G., Pichler, R., Zelger, B. et al. Prevalence of the human papillomavirus (HPV) expression of the inner prepuce in asymptomatic boys and men. World J Urol 31, 1389–1394 (2013). https://doi.org/10.1007/s00345-012-0997-8

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  • DOI: https://doi.org/10.1007/s00345-012-0997-8

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