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The impact of signet-ring cell carcinoma histology on bladder cancer outcome

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Abstract

Background

Signet-ring cell carcinoma (SRCC) of the urinary bladder is a rare entity. No previous studies have directly compared the cancer-specific survival of patients with SRCC to patients with urothelial carcinoma (UC) of the urinary bladder.

Materials and methods

Patients with diagnosis of urinary bladder SRCC and UC were identified in the Surveillance, epidemiology, and end results program (SEER) (2001–2004). Demographic of patients and clinical characteristics at diagnosis were compared. Differences in cancer-specific survival were compared using univariate and multivariate analysis.

Results

A total of 103 patients with SRCC and 14,648 patients with UC were indentified. Patients with SRCC were younger (P < 0.001), more commonly presented with higher-grade histology (P < 0.001) and advanced stage disease (P < 0.001), in comparison with patients with UC. The 3-year cancer-specific survival rate was 67.0% for patients with UC and 33.2% for SRCC. On multivariate analysis, there was an increased mortality risk in patients with SRCC versus UC (HR 1.49, 95% CI 1.11–2.00, P < 0.01).

Conclusions

Even after adjusting for demographic, surgical, and pathological factors, cancer-specific survival rate was significantly worse in patients with SRCC compared to UC. Further research into the biology of this rare tumor is required to explain these results.

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References

  1. Saphir O (1955) Signet-ring cell carcinoma of the urinary bladder. Am J Pathol 31:223–231

    PubMed  CAS  Google Scholar 

  2. Holmang S, Borghede G, Johansson SL (1997) Primary signet ring cell carcinoma of the bladder: a report on 10 cases. Scand J Urol Nephrol 31:145–148

    Article  PubMed  CAS  Google Scholar 

  3. Jakse G, Schneider H, Jacobi G (1978) Urachal signet-ring cell carcinoma, a rare variant of vesical adenocarcinoma: incidence and pathological criteria. J Urol 120:764–766

    PubMed  CAS  Google Scholar 

  4. Kume H, Kanai Y, Tobisu K, Fujimoto H, Tomita K, Kakizoe T (2000) Signet-ring cell carcinoma of the urinary bladder associated with transitional cell carcinoma of the right ureter. Scand J Urol Nephrol 34:278–279

    Article  PubMed  CAS  Google Scholar 

  5. Shinagawa T, Tadokoro M, Abe M, Koshitaka Y, Kouno S, Hoshino T (1998) Papillaryurothelial carcinoma of the urinary bladder demonstrating prominent signet-ring cells in a smear. a case report. Acta Cytol 42:407–412

    Article  PubMed  CAS  Google Scholar 

  6. Fernandez-Arjona M, Herrero L, Romero JC, Nieto S, Martin R, Pereira I (1996) Synchronous signet ring cell carcinoma and squamous cell carcinoma arising in an augmented ileocystoplasty. Case report and review of the literature. Eur Urol 29:125–128

    PubMed  CAS  Google Scholar 

  7. Kunze E, Francksen B (2002) Histogenesis of nonurothelial carcinomas of the urinary bladder from pre-existent transitional cell carcinomas. A histopathological and immunohistochemical study. Urol Res 30:66–78

    Article  PubMed  CAS  Google Scholar 

  8. Kondo A, Ogisu B, Mitsuya H (1981) Signet-ring cell carcinoma involving the urinary bladder: report of a case and review of 21 cases. Urol Int 36:373–379

    Article  PubMed  CAS  Google Scholar 

  9. Kim SS, Choi YD, Nam JH, Kwon DD, Juhng SW, Choi C (2009) Cytologic features of primary signet ring cell carcinoma of the bladder: a case report. Acta Cytol 53:309–312

    Article  PubMed  Google Scholar 

  10. Del Sordo R, Bellezza G, Colella R, Mameli MG, Sidoni A, Cavaliere A (2009) Primary signet-ring cell carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical study of 5 cases. Appl Immunohistochem Mol Morphol 17:18–22

    Article  PubMed  Google Scholar 

  11. DeMay RM, Grathwohl MA (1985) Signet-ring-cell (colloid) carcinoma of the urinary bladder. cytologic, histologic and ultrastructural findings in one case. Acta Cytol 29:132–136

    PubMed  CAS  Google Scholar 

  12. Ohtsuki Y, Fukumoto T, Okada Y, Teratani Y, Hayashi Y, Lee GH, Furihata M (2010) Immunohistochemical and ultrastructural characterization of the signet-ring cell carcinoma component in a case of urothelial carcinoma of the urinary bladder. Med Mol Morphol 43:96–101

    Article  PubMed  CAS  Google Scholar 

  13. Ponz M, Luzuriaga J, Robles JE, Guillén F, Urmeneta JM, Salvá A, Zudaire JJ, Berián JM (1985) Primary signet-ring cell carcinoma of the urinary bladder (linitis plastica). Eur Urol 11:212–214

    PubMed  CAS  Google Scholar 

  14. Choi H, Lamb S, Pintar K, Jacobs SC (1984) Primary signet-ring cell carcinoma of the urinary bladder. Cancer 53:1985–1990

    Article  PubMed  CAS  Google Scholar 

  15. Austin GE, Safford J (1978) Signet ring cell carcinoma of bladder. Urology 12:458–460

    Article  PubMed  CAS  Google Scholar 

  16. Kunze E, Francksen B, Schulz H (2001) Expression of MUC5AC apomucin in transitional cell carcinomas of the urinary bladder and its possible role in the development of mucus-secreting adenocarcinomas. Virchows Arch 439:609–615

    PubMed  CAS  Google Scholar 

  17. Kunze E (1998) Histogenesis of nonurothelial carcinomas in the human and rat urinary bladder. Exp Toxicol Pathol 50:341–355

    Article  PubMed  CAS  Google Scholar 

  18. Grignon DJ, Ro JY, Ayala AG, Johnson DE (1991) Primary signet-ring cell carcinoma of the urinary bladder. Am J Clin Pathol 95:13–20

    PubMed  CAS  Google Scholar 

  19. Surveillance, Epidemiology, and End Results (SEER) Program. Public-Use Data (1973–2004), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch. Available at: http://www.seer.cancer.gov/about/expansion.html. Accessed: November 2007

  20. Kaplan EL, Meier P (1985) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481

    Article  Google Scholar 

  21. Cox DR (1972) Regression models and life-tables. J R Stat Soc B 34:187–220

    Google Scholar 

  22. Akamatsu S, Takahashi A, Ito M, Ogura K (2010) Primary signet-ring cell carcinoma of the urinary bladder. Urology 75:615–618

    Article  PubMed  Google Scholar 

  23. Thomas AA, Stephenson AJ, Campbell SC, Jones JS, Hansel DE (2009) Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladder. Hum Pathol 40:108–116

    Article  PubMed  CAS  Google Scholar 

  24. Cabibi D, Calascibetta A, Aragona F, Martorana A, Campione M, Sanguedolce R (2009) Differing expression of metalloprotease and of adhesion molecules in signet-ring cell and intestinal colorectal carcinoma. Anticancer Res 29:4417–4422

    PubMed  Google Scholar 

  25. Lim MG, Adsay NV, Grignon DJ, Osunkoya AO (2011) E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma. Mod Pathol 24:241–247

    Article  PubMed  CAS  Google Scholar 

  26. Shanks JH, Iczkowski KA (2009) Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics. Histopathology 54(7):885–900

    Article  PubMed  CAS  Google Scholar 

  27. Eble JN, Young RH (1997) Carcinoma of the urinary bladder: a review of its diverse morphology. Semin Diagn Pathol 14(2):98–108

    PubMed  CAS  Google Scholar 

  28. Sanchez-Carbayo M, Socci ND, Charytonowicz E, Lu M, Prystowsky M, Childs G, Cordon-Cardo C (2002) Molecular profiling of bladder cancer using cDNA microarrays: defining histogenesis and biological phenotypes. Cancer Res 62:6973–6980

    PubMed  CAS  Google Scholar 

  29. Blaveri E, Simko JP, Korkola JE, Brewer JL, Baehner F, Mehta K, Devries S, Koppie T, Pejavar S, Carroll P, Waldman FM (2005) Bladder cancer outcome and subtype classification by gene expression. Clin Cancer Res 11:4044–4055

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors acknowledge the efforts of the Applied Research Branch, Division of Cancer Prevention and Population Science, NCI; and the Surveillance, Epidemiology, and End Results (SEER) Program tumor registries. Interpretation and reporting of these data are solely the responsibility of the authors.

Conflict of interest

The authors certify that there is no actual or potential conflict of interest in relation to this article.

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Authors and Affiliations

  1. Department of Internal Medicine, Creighton University Medical School, Omaha, NE, 68131, USA

    Fen Wei Wang

  2. Division of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198-7680, USA

    Jue Wang & Anne Kessinger

Authors
  1. Jue Wang
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  2. Fen Wei Wang
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  3. Anne Kessinger
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Correspondence to Jue Wang.

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Wang, J., Wang, F.W. & Kessinger, A. The impact of signet-ring cell carcinoma histology on bladder cancer outcome. World J Urol 30, 777–783 (2012). https://doi.org/10.1007/s00345-011-0718-8

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  • DOI: https://doi.org/10.1007/s00345-011-0718-8

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