Mammalian Genome

, Volume 23, Issue 9, pp 680–692

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

Authors

  • Anatole Ghazalpour
    • Department of Medicine, David Geffen School of MedicineUniversity of California
  • Christoph D. Rau
    • Department of Microbiology, Immunology and Molecular GeneticsUniversity of California
  • Charles R. Farber
    • Departments of Medicine and Biochemistry and Molecular Genetics, and Center for Public Health GenomicsUniversity of Virginia
  • Brian J. Bennett
    • Department of Genetics, and Nutrition Research InstituteUniversity of North Carolina
  • Luz D. Orozco
    • Department of Human Genetics, David Geffen School of MedicineUniversity of California
  • Atila van Nas
    • Department of Human Genetics, David Geffen School of MedicineUniversity of California
  • Calvin Pan
    • Department of Human Genetics, David Geffen School of MedicineUniversity of California
  • Hooman Allayee
    • Department of Preventive Medicine, Keck School of MedicineUniversity of Southern California
  • Simon W. Beaven
    • Division of Digestive Diseases, Department of Medicine, David Geffen School of MedicineUniversity of California
  • Mete Civelek
    • Department of Medicine, David Geffen School of MedicineUniversity of California
  • Richard C. Davis
    • Department of Medicine, David Geffen School of MedicineUniversity of California
  • Thomas A. Drake
    • Department of Pathology and Laboratory Medicine, David Geffen School of MedicineUniversity of California
  • Rick A. Friedman
    • Department of Otology/Skull Base SurgeryHouse Research Institute
  • Nick Furlotte
    • Department of Computer SciencesUniversity of California
  • Simon T. Hui
    • Department of Medicine, David Geffen School of MedicineUniversity of California
  • J. David Jentsch
    • Department of Psychology & Behavioral Neuroscience and Psychiatry & Biobehavioral Sciences, David Geffen School of MedicineUniversity of California
  • Emrah Kostem
    • Department of Computer SciencesUniversity of California
  • Hyun Min Kang
    • Department of Biostatistics, School of Public HealthUniversity of Michigan
  • Eun Yong Kang
    • Department of Computer SciencesUniversity of California
  • Jong Wha Joo
    • Department of Human Genetics, David Geffen School of MedicineUniversity of California
    • Bioinformatics Program, David Geffen School of MedicineUniversity of California
  • Vyacheslav A. Korshunov
    • Department of Medicine, Aab Cardiovascular Research InstituteUniversity of Rochester School of Medicine and Dentistry
  • Rick E. Laughlin
    • Semel Institute for Neuroscience and Human BehaviorUniversity of California
  • Lisa J. Martin
    • Department of Human Genetics, David Geffen School of MedicineUniversity of California
  • Jeffrey D. Ohmen
    • Department of Cell Biology and GeneticsHouse Research Institute
  • Brian W. Parks
    • Department of Medicine, David Geffen School of MedicineUniversity of California
  • Matteo Pellegrini
    • Department of Molecular, Cell and Developmental BiologyUniversity of California
  • Karen Reue
    • Department of Human Genetics, David Geffen School of MedicineUniversity of California
  • Desmond J. Smith
    • Department of Molecular and Medical Pharmacology, David Geffen School of MedicineUniversity of California
  • Sotirios Tetradis
    • Molecular Biology Institute, David Geffen School of MedicineUniversity of California
    • Division of Diagnostic and Surgical Science, School of DentistryUniversity of California
  • Jessica Wang
    • Department of Human Genetics, David Geffen School of MedicineUniversity of California
    • Department of Medicine/Cardiology, David Geffen School of MedicineUniversity of California
  • Yibin Wang
    • Division of Molecular Medicine, Department of Anesthesiology, Physiology and Medicine, David Geffen School of MedicineUniversity of California
  • James N. Weiss
    • Department of Microbiology, Immunology and Molecular GeneticsUniversity of California
  • Todd Kirchgessner
    • Department of Cardiovascular Drug DiscoveryBristol-Myers Squibb Co
  • Peter S. Gargalovic
    • Department of Cardiovascular Drug DiscoveryBristol-Myers Squibb Co
  • Eleazar Eskin
    • Department of Human Genetics, David Geffen School of MedicineUniversity of California
    • Department of Computer SciencesUniversity of California
  • Aldons J. Lusis
    • Department of Medicine, David Geffen School of MedicineUniversity of California
    • Department of Microbiology, Immunology and Molecular GeneticsUniversity of California
    • Department of Human Genetics, David Geffen School of MedicineUniversity of California
    • Division of Diagnostic and Surgical Science, School of DentistryUniversity of California
    • Division of Metabolism, Endocrinology and Nutrition, Department of MedicineUniversity of Washington
Article

DOI: 10.1007/s00335-012-9411-5

Cite this article as:
Ghazalpour, A., Rau, C.D., Farber, C.R. et al. Mamm Genome (2012) 23: 680. doi:10.1007/s00335-012-9411-5

Abstract

We have developed an association-based approach using classical inbred strains of mice in which we correct for population structure, which is very extensive in mice, using an efficient mixed-model algorithm. Our approach includes inbred parental strains as well as recombinant inbred strains in order to capture loci with effect sizes typical of complex traits in mice (in the range of 5 % of total trait variance). Over the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes and have shown that the HMDP has sufficient power to map genes for highly complex traits with resolution that is in most cases less than a megabase. In this essay, we review our experience with the HMDP, describe various ongoing projects, and discuss how the HMDP may fit into the larger picture of common diseases and different approaches.

Copyright information

© Springer Science+Business Media, LLC 2012