Article

Mammalian Genome

, Volume 23, Issue 9, pp 680-692

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

  • Anatole GhazalpourAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of California
  • , Christoph D. RauAffiliated withDepartment of Microbiology, Immunology and Molecular Genetics, University of California
  • , Charles R. FarberAffiliated withDepartments of Medicine and Biochemistry and Molecular Genetics, and Center for Public Health Genomics, University of Virginia
  • , Brian J. BennettAffiliated withDepartment of Genetics, and Nutrition Research Institute, University of North Carolina
  • , Luz D. OrozcoAffiliated withDepartment of Human Genetics, David Geffen School of Medicine, University of California
  • , Atila van NasAffiliated withDepartment of Human Genetics, David Geffen School of Medicine, University of California
  • , Calvin PanAffiliated withDepartment of Human Genetics, David Geffen School of Medicine, University of California
  • , Hooman AllayeeAffiliated withDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California
  • , Simon W. BeavenAffiliated withDivision of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California
    • , Mete CivelekAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of California
    • , Richard C. DavisAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of California
    • , Thomas A. DrakeAffiliated withDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California
    • , Rick A. FriedmanAffiliated withDepartment of Otology/Skull Base Surgery, House Research Institute
    • , Nick FurlotteAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Computer Sciences, University of California
    • , Simon T. HuiAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of California
    • , J. David JentschAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Psychology & Behavioral Neuroscience and Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California
    • , Emrah KostemAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Computer Sciences, University of California
    • , Hyun Min KangAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Biostatistics, School of Public Health, University of Michigan
    • , Eun Yong KangAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Computer Sciences, University of California
    • , Jong Wha JooAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Human Genetics, David Geffen School of Medicine, University of CaliforniaBioinformatics Program, David Geffen School of Medicine, University of California
    • , Vyacheslav A. KorshunovAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry
    • , Rick E. LaughlinAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaSemel Institute for Neuroscience and Human Behavior, University of California
    • , Lisa J. MartinAffiliated withDepartment of Human Genetics, David Geffen School of Medicine, University of California
    • , Jeffrey D. OhmenAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Cell Biology and Genetics, House Research Institute
    • , Brian W. ParksAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of California
    • , Matteo PellegriniAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Molecular, Cell and Developmental Biology, University of California
    • , Karen ReueAffiliated withDepartment of Human Genetics, David Geffen School of Medicine, University of California
    • , Desmond J. SmithAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California
    • , Sotirios TetradisAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Microbiology, Immunology and Molecular Genetics, University of CaliforniaMolecular Biology Institute, David Geffen School of Medicine, University of CaliforniaDivision of Diagnostic and Surgical Science, School of Dentistry, University of California
    • , Jessica WangAffiliated withDepartment of Microbiology, Immunology and Molecular Genetics, University of CaliforniaDepartment of Human Genetics, David Geffen School of Medicine, University of CaliforniaDepartment of Medicine/Cardiology, David Geffen School of Medicine, University of California
    • , Yibin WangAffiliated withDepartment of Microbiology, Immunology and Molecular Genetics, University of CaliforniaDivision of Molecular Medicine, Department of Anesthesiology, Physiology and Medicine, David Geffen School of Medicine, University of California
    • , James N. WeissAffiliated withDepartment of Microbiology, Immunology and Molecular Genetics, University of California
    • , Todd KirchgessnerAffiliated withDepartment of Microbiology, Immunology and Molecular Genetics, University of CaliforniaDepartment of Cardiovascular Drug Discovery, Bristol-Myers Squibb Co
    • , Peter S. GargalovicAffiliated withDepartment of Microbiology, Immunology and Molecular Genetics, University of CaliforniaDepartment of Cardiovascular Drug Discovery, Bristol-Myers Squibb Co
    • , Eleazar EskinAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Human Genetics, David Geffen School of Medicine, University of CaliforniaDepartment of Computer Sciences, University of California
    • , Aldons J. LusisAffiliated withDepartment of Medicine, David Geffen School of Medicine, University of CaliforniaDepartment of Microbiology, Immunology and Molecular Genetics, University of CaliforniaDepartment of Human Genetics, David Geffen School of Medicine, University of CaliforniaDivision of Diagnostic and Surgical Science, School of Dentistry, University of California
    • , Renée C. LeBoeufAffiliated withDepartment of Microbiology, Immunology and Molecular Genetics, University of CaliforniaDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

We have developed an association-based approach using classical inbred strains of mice in which we correct for population structure, which is very extensive in mice, using an efficient mixed-model algorithm. Our approach includes inbred parental strains as well as recombinant inbred strains in order to capture loci with effect sizes typical of complex traits in mice (in the range of 5 % of total trait variance). Over the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes and have shown that the HMDP has sufficient power to map genes for highly complex traits with resolution that is in most cases less than a megabase. In this essay, we review our experience with the HMDP, describe various ongoing projects, and discuss how the HMDP may fit into the larger picture of common diseases and different approaches.