Mammalian Genome

, Volume 16, Issue 9, pp 720–730

Quantitative trait loci for hip dysplasia in a crossbreed canine pedigree

Authors

    • Department of Clinical Sciences, Box 32 College of Veterinary MedicineCornell University
  • Raluca Mateescu
    • Department of Clinical Sciences, Box 32 College of Veterinary MedicineCornell University
  • George Lust
    • James A. Baker Institute for Animal Health, College of Veterinary MedicineCornell University
  • Nancy I. Burton-Wurster
    • James A. Baker Institute for Animal Health, College of Veterinary MedicineCornell University
  • Nathan L. Dykes
    • Department of Clinical Sciences, Box 32 College of Veterinary MedicineCornell University
  • Stuart P. Bliss
    • Department of Clinical Sciences, Box 32 College of Veterinary MedicineCornell University
  • Alma J. Williams
    • James A. Baker Institute for Animal Health, College of Veterinary MedicineCornell University
  • Margaret Vernier-Singer
    • Department of Clinical Sciences, Box 32 College of Veterinary MedicineCornell University
  • Elizabeth Corey
    • James A. Baker Institute for Animal Health, College of Veterinary MedicineCornell University
  • Carlos Harjes
    • Department of Clinical Sciences, Box 32 College of Veterinary MedicineCornell University
  • Richard L. Quaas
    • Department of Animal Breeding, College of Agriculture and Life SciencesCornell University
  • Zhiwu Zhang
    • Department of Animal Breeding, College of Agriculture and Life SciencesCornell University
  • Robert O. Gilbert
    • Department of Clinical Sciences, Box 32 College of Veterinary MedicineCornell University
  • Dietrich Volkman
    • Department of Clinical Sciences, Box 32 College of Veterinary MedicineCornell University
  • George Casella
    • Department of StatisticsUniversity of Florida
  • Rongling Wu
    • Department of StatisticsUniversity of Florida
  • Gregory M. Acland
    • James A. Baker Institute for Animal Health, College of Veterinary MedicineCornell University
Article

DOI: 10.1007/s00335-005-0004-4

Cite this article as:
Todhunter, R.J., Mateescu, R., Lust, G. et al. Mamm Genome (2005) 16: 720. doi:10.1007/s00335-005-0004-4

Abstract

Canine hip dysplasia is a common developmental inherited trait characterized by hip laxity, subluxation or incongruity of the femoral head and acetabulum in affected hips. The inheritance pattern is complex and the mutations contributing to trait expression are unknown. In the study reported here, 240 microsatellite markers distributed in 38 autosomes and the X chromosome were genotyped on 152 dogs from three generations of a crossbred pedigree based on trait-free Greyhound and dysplastic Labrador Retriever founders. Interval mapping was undertaken to map the QTL underlying the quantitative dysplastic traits of maximum passive hip laxity (the distraction index), the dorsolateral subluxation score, and the Norberg angle. Permutation testing was used to derive the chromosome-wide level of significance at p < 0.05 for each QTL. Chromosomes 4, 9, 10, 11 (p < 0.01), 16, 20, 22, 25, 29 (p < 0.01), 30, 35, and 37 harbor putative QTL for one or more traits. Successful detection of QTL was due to the crossbreed pedigree, multiple-trait measurements, control of environmental background, and marked advancement in canine mapping tools.

Copyright information

© Springer Science+Business Media, Inc. 2005