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Expanded polytetrafluoroethylene-covered stent-grafts for transjugular intrahepatic portosystemic shunts in cirrhotic patients: Long-term patency and clinical outcome results

  • Vascular-Interventional
  • Published:
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Abstract

Purpose

To retrospectively analyse long-term patency and overall survival of cirrhotic patients treated with TIPSS using e-PTFE-covered stents. Additionally, prognostic factors for better patency and survival were analysed.

Materials and methods

Two hundred and eighty-five consecutive cirrhotic patients with severe portal hypertension-related symptoms were included. Follow-up, including clinical assessment and duplex ultrasound, was analysed up to end of study, patient’s death, liver transplantation or TIPSS-reduction. Patency rates and overall survival were estimated by the Kaplan-Meier method; potential differences in outcome between subgroups were calculated using the Pepe and Mori test.

Results

The 1-, 2- and 5-year primary patencies were 91.5 %, 89.2 % and 86.2 %, respectively, with no new shunt dysfunctions after 5 years’ follow-up. TIPSS revision was performed more often in ascites patients (P = 0.02). The 1-, 4- and 10-year survival rates were 69.2 %, 52.1 % and 30.7 %, respectively. Survival was higher in Child-Pugh class A-B (P = 0.04), in the recurrent bleeding group (P = 0.008) and in patients with underlying alcoholic cirrhosis (P = 0.01).

Conclusion

Long term, primary patency of e-PTFE-covered TIPSS stents remains very high (>80 %); shunt revision was required more frequently in ascites patients. Overall survival was better in Child-Pugh A-B patients with recurrent variceal bleeding and alcoholic liver cirrhosis.

Keypoints

• Long-term primary patency rate of e-PTFE-covered TIPSS stents remains very high.

• No new shunt dysfunction was found after 5 years of follow-up.

• Shunt revision was required more frequently in ascites patients.

• Four and 10 years’ overall survival was 50 and 30 %, respectively.

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Acknowledgments

The scientific guarantor of this publication is Geert Maleux. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. The Interuniversity Institute for Biostatistics and Statistical Bioinformatics, KU Leuven and University of Hasselt, Belgium kindly provided statistical advice for this manuscript. Institutional Review Board approval was obtained.

Written informed consent was not required for this study because it was a retrospective, observational study. Methodology: retrospective, observational, performed at one institution.

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Authors and Affiliations

  1. Department of Radiology, University Hospitals Leuven, Herestraat 49, B-3000, Leuven, Belgium

    Barbara Geeroms, Sam Heye & Geert Maleux

  2. Department of Imaging and Pathology, KU Leuven, Leuven, Belgium

    Barbara Geeroms, Sam Heye & Geert Maleux

  3. Department of Hepatology, University Hospitals Leuven, Leuven, Belgium

    Wim Laleman, Chris Verslype, Schalk van der Merwe & Frederik Nevens

  4. Interuniversity Institute for Biostatistics and Statistical Bioinformatics, KU Leuven, Leuven, Belgium

    Annouschka Laenen

  5. University of Hasselt, Hasselt, Belgium

    Annouschka Laenen

Authors
  1. Barbara Geeroms
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  2. Wim Laleman
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  3. Annouschka Laenen
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  4. Sam Heye
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  5. Chris Verslype
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  6. Schalk van der Merwe
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  7. Frederik Nevens
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  8. Geert Maleux
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Corresponding author

Correspondence to Geert Maleux.

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Geeroms, B., Laleman, W., Laenen, A. et al. Expanded polytetrafluoroethylene-covered stent-grafts for transjugular intrahepatic portosystemic shunts in cirrhotic patients: Long-term patency and clinical outcome results. Eur Radiol 27, 1795–1803 (2017). https://doi.org/10.1007/s00330-016-4570-5

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  • DOI: https://doi.org/10.1007/s00330-016-4570-5

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