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CT-based compartmental quantification of adipose tissue versus body metrics in colorectal cancer patients

  • Oncology
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Abstract

Purpose

While obesity is considered a prognostic factor in colorectal cancer (CRC), there is increasing evidence that not simply body mass index (BMI) alone but specifically abdominal fat distribution is what matters. As part of the ColoCare study, this study measured the distribution of adipose tissue compartments in CRC patients and aimed to identify the body metric that best correlates with these measurements as a useful proxy for adipose tissue distribution.

Materials and methods

In 120 newly-diagnosed CRC patients who underwent multidetector computed tomography (CT), densitometric quantification of total (TFA), visceral (VFA), intraperitoneal (IFA), retroperitoneal (RFA), and subcutaneous fat area (SFA), as well as the M. erector spinae and psoas was performed to test the association with gender, age, tumor stage, metabolic equivalents, BMI, waist-to-height (WHtR) and waist–to-hip ratio (WHR).

Results

VFA was 28.8 % higher in men (pVFA<0.0001) and 30.5 % higher in patients older than 61 years (pVFA<0.0001). WHtR correlated best with all adipose tissue compartments (rVFA=0.69, rTFA=0.84, p<0.0001) and visceral-to-subcutaneous-fat-ratio (VFR, rVFR=0.22, p=<0.05). Patients with tumor stages III/IV showed significantly lower overall adipose tissue than I/II. Increased M. erector spinae mass was inversely correlated with all compartments.

Conclusion

Densitometric quantification on CT is a highly reproducible and reliable method to show fat distribution across adipose tissue compartments. This distribution might be best reflected by WHtR, rather than by BMI or WHR.

Key Points

Densitometric quantification of adipose tissue on CT is highly reproducible and reliable.

Waist-to-height ratio better correlates with adipose tissue compartments and VFR than BMI or waist-to-hip ratio.

Men have higher a higher visceral fat area than women.

Patients older than 61 years have higher visceral fat area.

Patients with tumor stages III/IV have significantly lower adipose tissue than those in stages I/II.

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Acknowledgments

The scientific guarantor of this publication is Prof. H.U. Kauczor. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The ColoCare study has received funding by the Lackas Foundation and the DKTK (German Consortium for Translational Cancer Research). B. Gigic and M. Paskow of the authors had significant statistical expertise. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: retrospective, diagnostic or prognostic study, multicenter study: ColoCare/ performed at one institution: this was part of the ColoCare Study.

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Correspondence to Johanna Nattenmueller.

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C.M. Ulrich and H.U. Kauczor contributed equally to this work as joint senior authors.

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Nattenmueller, J., Hoegenauer, H., Boehm, J. et al. CT-based compartmental quantification of adipose tissue versus body metrics in colorectal cancer patients. Eur Radiol 26, 4131–4140 (2016). https://doi.org/10.1007/s00330-016-4231-8

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  • DOI: https://doi.org/10.1007/s00330-016-4231-8

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