European Radiology

, Volume 26, Issue 7, pp 2317–2326

Correlation between conductivity and prognostic factors in invasive breast cancer using magnetic resonance electric properties tomography (MREPT)

  • Soo-Yeon Kim
  • Jaewook Shin
  • Dong-Hyun Kim
  • Min Jung Kim
  • Eun-Kyung Kim
  • Hee Jung Moon
  • Jung Hyun Yoon
Breast

DOI: 10.1007/s00330-015-4067-7

Cite this article as:
Kim, SY., Shin, J., Kim, DH. et al. Eur Radiol (2016) 26: 2317. doi:10.1007/s00330-015-4067-7

Abstract

Purpose

To investigate the correlation between conductivity and prognostic factors of invasive breast cancer using magnetic resonance electric properties tomography (MREPT).

Methods

This retrospective study was approved by the Institutional Review Board, and verbal informed consent was obtained prior to breast MRI. This study included 65 women with surgically confirmed invasive breast cancers measuring 1 cm or larger on T2-weighted fast spin echo (FSE). Phase-based MREPT and the coil combination technique were used to reconstruct conductivity. Simple and multiple linear regression analysis were used to find an independent factor associated with conductivity.

Results

In total tumours, tumours with HER-2 overexpression showed lower conductivity than those without, and HER-2 overexpression was independently associated with conductivity. In 37 tumours 2 cm or larger, tumours with high mitosis or PR positivity showed higher conductivity than those without, and high mitosis and PR positivity were independently associated with conductivity. In 28 tumours 1–2 cm in size, there were no differences in conductivity according to the prognostic factors.

Conclusion

Conductivity values measured using MREPT are associated with the HER-2 overexpression status, and may provide information about mitosis and the PR status of invasive breast cancers 2 cm or larger.

Key Points

In all tumours, HER-2 overexpression was independently associated with conductivity.

In tumours ≥ 2 cm, high mitosis and PR positivity were associated with conductivity.

Conductivity is associated with the HER-2 overexpression status of invasive breast cancers.

Keywords

Electric conductivity Magnetic resonance imaging Breast cancer HER-2 Mitosis 

Copyright information

© European Society of Radiology 2015

Authors and Affiliations

  • Soo-Yeon Kim
    • 1
  • Jaewook Shin
    • 2
  • Dong-Hyun Kim
    • 2
  • Min Jung Kim
    • 1
  • Eun-Kyung Kim
    • 1
  • Hee Jung Moon
    • 1
  • Jung Hyun Yoon
    • 1
  1. 1.Department of Radiology and Research Institute of Radiological Science, Severance HospitalYonsei University College of MedicineSeodaemun-guKorea
  2. 2.Department of Electrical and Electronic EngineeringYonsei UniversitySeoulKorea