Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
To retrospectively investigate enhancement patterns of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) in the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced MRI in relation to histological grading and portal blood flow.
Sixty-nine consecutive patients with 83 histologically proven HCCs and DNs were studied. To assess Gd-EOB-DTPA uptake, we calculated the EOB enhancement ratio, which is the ratio of the relative intensity of tumorous lesion to surrounding nontumorous area on hepatobiliary phase images (post-contrast EOB ratio) to that on unenhanced images (pre-contrast EOB ratio). Portal blood flow was evaluated by CT during arterial portography.
Post-contrast EOB ratios significantly decreased as the degree of differentiation declined in DNs (1.00 ± 0.14) and well, moderately and poorly differentiated HCCs (0.79 ± 0.19, 0.60 ± 0.27, 0.49 ± 0.10 respectively). Gd-EOB-DTPA uptake, assessed by EOB enhancement ratios, deceased slightly in DNs and still more in HCCs, while there was no statistical difference in the decrease between different histological grades of HCC. Reductions in portal blood flow were observed less frequently than decreases in Gd-EOB-DTPA uptake in DNs and well-differentiated HCCs.
Reduced Gd-EOB-DTPA uptake might be an early event of hepatocarcinogenesis, preceding portal blood flow reduction. The hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI may help estimate histological grading, although difficulties exist in differentiating HCCs from DNs.
- Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow
Volume 20, Issue 10 , pp 2405-2413
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Gd-EOB-DTPA-enhanced MR imaging
- Hepatocellular carcinoma
- Dysplastic nodule
- Histological grading
- Portal blood flow
- Industry Sectors
- Author Affiliations
- 1. Department of Gastroenterology, Ikeda Municipal Hospital, 3-1-18, Johnan, Ikeda, Osaka, 563-8510, Japan
- 2. Department of Radiology, Kinki University School of Medicine, Osaka, Japan
- 3. Department of Radiology, Osaka University Graduate School of Medicine, Osaka, Japan
- 4. Department of Radiology, Ikeda Municipal Hospital, Osaka, Japan
- 5. Department of Surgery, Ikeda Municipal Hospital, Osaka, Japan
- 6. Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
- 7. Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan
- 8. Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan