Cardiac

European Radiology

, Volume 19, Issue 3, pp 591-598

ACCURATUM: improved calcium volume scoring using a mesh-based algorithm—a phantom study

  • Stefan C. SaurAffiliated withComputer Vision Laboratory, ETH Zurich
  • , Hatem AlkadhiAffiliated withInstitute of Diagnostic Radiology, University Hospital ZurichDepartment of Medical Radiology, Institute of Diagnostic Radiology, University Hospital Zurich Email author 
  • , Lotus DesbiollesAffiliated withInstitute of Diagnostic Radiology, University Hospital Zurich
  • , Gábor SzékelyAffiliated withComputer Vision Laboratory, ETH Zurich
  • , Philippe C. CattinAffiliated withComputer Vision Laboratory, ETH ZurichCMBE, University of Basel

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Abstract

To overcome the limitations of the classical volume scoring method for quantifying coronary calcifications, including accuracy, variability between examinations, and dependency on plaque density and acquisition parameters, a mesh-based volume measurement method has been developed. It was evaluated and compared with the classical volume scoring method for accuracy, i.e., the normalized volume (measured volume/ground-truthed volume), and for variability between examinations (standard deviation of accuracy). A cardiac computed-tomography (CT) phantom containing various cylindrical calcifications was scanned using different tube voltages and reconstruction kernels, at various positions and orientations on the CT table and using different slice thicknesses. Mean accuracy for all plaques was significantly higher (p < 0.0001) for the proposed method (1.220 ± 0.507) than for the classical volume score (1.896 ± 1.095). In contrast to the classical volume score, plaque density (p = 0.84), reconstruction kernel (p = 0.19), and tube voltage (p = 0.27) had no impact on the accuracy of the developed method. In conclusion, the method presented herein is more accurate than classical calcium scoring and is less dependent on tube voltage, reconstruction kernel, and plaque density.

Keywords

Coronary calcium Volume Computed tomography