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Updates on cardiovascular comorbidities associated with psoriatic diseases: epidemiology and mechanisms

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Abstract

Psoriasis and psoriatic arthritis are associated with a significantly increased risk of cardiovascular risk factors and major adverse cardiovascular events (MACE). Active research is ongoing to elucidate this relationship between psoriatic diseases and cardiovascular comorbidities, as well as their shared pathogenic mechanisms. This review focuses on (1) the epidemiologic association between psoriasis and cardiovascular risk factors, (2) the epidemiologic association between psoriasis and MACE, (3) the epidemiologic association between psoriatic arthritis, cardiovascular risk factors, and MACE, and (4) proposed mechanisms for the contribution of psoriatic diseases to cardiovascular diseases. The proposed mechanisms for shared pathogenesis between psoriatic diseases and cardiovascular diseases are inflammation, insulin resistance, dyslipidemia, angiogenesis, oxidative stress, and endothelial dysfunction. There is complex interplay and overlap among these mechanisms and their contributions to shared pathogenesis. Future translational research is necessary to elucidate the link between psoriatic diseases and cardiovascular diseases. Such findings may be applied clinically to improve the lives of psoriasis patients.

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  1. Department of Dermatology, University of Southern California, 1975 Zonal Avenue, KAM 510, MC 9034, Los Angeles, CA, 90089, USA

    Kaitlyn M. Yim & April W. Armstrong

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Ms. Kaitlyn M. Yim declares that she has no conflict of interest. Dr. April W. Armstrong is a consultant for and has received honorariums from Abbvie, Amgen, Celgene, Janssen, Merck, Lilly, Novartis, and Pfizer. Dr. Armstrong has also received grants from Abbvie, Janssen, and Lilly.

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Yim, K.M., Armstrong, A.W. Updates on cardiovascular comorbidities associated with psoriatic diseases: epidemiology and mechanisms. Rheumatol Int 37, 97–105 (2017). https://doi.org/10.1007/s00296-016-3487-2

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