Skip to main content

Advertisement

Log in

Behçet’s disease and comorbidity: internal case reports and literature review

  • Case Based Review - Cases with a Message
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

The aim of this study was to determine the clinical characteristics of two patients with malignancy related to Behçet’s disease. We reviewed literary-reported cases of Behçet’s disease related to myelodysplastic syndrome, neoplasm and leukemia. Our own observation included two cases of comorbid conditions of Behçet’s disease. The first patient with Behçet’s disease had been examined concurrent development of intestinal tumor. The second one was diagnosed to have chromic myeloleukemia. The malignant transformation of Behçet’s disease patients, both solid and hematological, is rather rare. Further accumulation of relevant date and its analysis will allow to find out the relationship between malignant disease and chemotherapy in Behçet’s disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Alekberova ZC (2013) Behçet’s disease. Scientific and Practical. Rheumatology 1:52–58

    Google Scholar 

  2. Yazici H, Esen F (2008) Mortality in Behcet’s syndrome. Clin Exp Rheumat 26(suppl. 51):S138–S140

    CAS  Google Scholar 

  3. Kaklamani VG, Tzonou A, Kaklamanis PG (2005) Behçet’s disease associated with malignancies. Report of two cases and review of the literature. Clin Exp Rheumatol 23(Suppl. 38):S35–S41

    CAS  PubMed  Google Scholar 

  4. Na SY (2013) Morbidity of solid cancer in Behcet’s disease: analysis of 11 cases in a series of 506 patients. Yonsei Med J 54(4):895–901

    Article  PubMed Central  PubMed  Google Scholar 

  5. International Study Group for Behcet’s Disease (1990) Criteria for diagnosis of Behcet’s disease. Lancet 335:1078–1080

    Google Scholar 

  6. Rutter M, Saunders B, Wilkinson K et al (2004) Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology 126:451–459

    Article  PubMed  Google Scholar 

  7. Jess T, Loftus EV Jr, Velayos FS et al (2006) Risk of intestinal cancer in inflammatory bowel disease: a population-based study from Olmsted County, Minnesota. Gastroenterology 130:1039–1046

    Article  PubMed  Google Scholar 

  8. Cengiz M, Altundag MK, Zorlu AF et al (2001) Malignancy in Behcet’s disease: a report of 13 cases and a review of the literature. Clin Rheumatol 20:239–244

    Article  CAS  PubMed  Google Scholar 

  9. Yamada M (2011) Colon cancer arising in an ulcer scar due to intestinal Behcet’s disease. Intern Med 50:429–432

    Article  PubMed  Google Scholar 

  10. Barhoumi A, Hamzaoni A, Hammami S, Manjoub S  (2008) Behcet`s disease associated with malignancies. Report of three cases. Clin Exp Rheum 26(suppl.50):S-21

    Google Scholar 

  11. Tassies D, Cervantes F, Feliu E et al (1992) Behcet’s disease with an onset prior to the appearance of chronic myeloid leukemia. Med Clin 99:67–68

    CAS  Google Scholar 

  12. Segawa F, Shimizu Y, Saito E, Kinoshita M (1995) Behcet’s disease induced by interferon therapy for chronic myelogenous leukemia. J Rheumatol 22:1183–1184

    CAS  PubMed  Google Scholar 

  13. Budak-Alpdogan T, Demircay Z, Alpdogan O et al (1997) Behcet’s disease in patients with chronic myelogenous leukemia: possible role of interferon-a treatment in the occurrence of Behcet’s symptoms. Ann Hematol 74:45–48

    Article  CAS  PubMed  Google Scholar 

  14. Vaiopoulos G, Terpos E, Viniou N et al (2001) Behcet’s disease in a patient with chronic myelogenous leukemia under hydroxyurea treatment: a case report and review of the literature. Am J Hematol 66:57–58

    Article  CAS  PubMed  Google Scholar 

  15. Budak-Alpdogan T, Demircay Z, Alpdogan O et al (1998) Skin hyperreactivity of Behcet’s patients (pathergy reaction) is also positive in interferon-a treated chronic myeloid leukaemia patients, indicating similarly altered neutrophil functions in both disorders. Br J Rheumatol 37:1148–1151

    Article  CAS  PubMed  Google Scholar 

  16. Vardiman JW, Melo JV, Baccarani M et al (2008) Chronic myelogenous leukaemia, BCR-ABL1 positive. In: Swerdlow SH, Campo E, Harris NL (eds) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. Lyon, IARC Press, pp 32–37

    Google Scholar 

  17. Tada Y, Koarada S, Haruta Y et al (2006) The association of Behçet’s disease with myelodysplastic syndrome in Japan: a review of the literature. Clin Exp Rheumatol 24(Suppl. 42):S115–S119

    CAS  PubMed  Google Scholar 

  18. Kimura S, Kuroda J, Akaogi T et al (2001) Trisomy 8 involved in myelodysplastic syndromes as a risk factor for intestinal ulcers and thrombosis in Behcet’s syndrome. Leuk Lymphoma 42:115–121

    Article  CAS  PubMed  Google Scholar 

  19. Eder L, Rozenbaum M, Boulman N et al (2005) Behcet`s disease, myelodysplastic syndrome trisomy 8, gastroenterological involvement—an association. Clin Exp Rheum 23(suppl 38):S91–S95

    CAS  Google Scholar 

  20. Lin YC, Liang TH, Chang HN et al (2008) Behçet disease associated with myelodysplastic syndrome. J Clin Rheumatol 14(3):169–174

    Article  PubMed  Google Scholar 

  21. Mantzourani M, Chantziara K, Thanopoulou I et al (2009) Coexistence of Behcet`s disease and chronic myelomonocyte leukemia with trisomy 8: a case report and review of the literature. Clin Exp Rheum 27(suppl. 53):S85–S87

    CAS  Google Scholar 

  22. Chen Huang-Chi, Chiu Ying-Ming (2012) Large-vessel thrombosis in intestinal Behçet’s disease complicated with myelodysplastic syndrome and trisomy 8. World J Gastroenterol 18(10):1137–1140

    Article  PubMed Central  PubMed  Google Scholar 

  23. Safe T, Ontsuka H, Safo M, et al. Remission of intestinal Behçet’s disease after induction chemotherapy into acute myeloid leukemia M4 inv16. 15th Intern Conference on Behcet’s disease. Abstract book 13–15 July 2012 Yokohama, p 6-1-099 p 88

  24. Lim SH, Hulsey M, Esler WV (2009) Resolution of Behcet’s disease after non-myeloablative allogeneic stem cell transplant for acute myeloid leukaemia. Rheumatology 48:88–89

    Article  CAS  PubMed  Google Scholar 

  25. Tomonari A, Tojo A, Takahashi T et al (2004) Resolution of Behcet’s disease after HLA-mismatched unrelated cord blood transplantation for myelodysplastic syndrome. Ann Hematol 83:464–466

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fatima Izmailova.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Alekberova, Z., Gorodetskiy, V., Izmailova, F. et al. Behçet’s disease and comorbidity: internal case reports and literature review. Rheumatol Int 35, 1743–1747 (2015). https://doi.org/10.1007/s00296-015-3232-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-015-3232-2

Keywords

Navigation