Abstract
The aim of this study was to determine the clinical characteristics of two patients with malignancy related to Behçet’s disease. We reviewed literary-reported cases of Behçet’s disease related to myelodysplastic syndrome, neoplasm and leukemia. Our own observation included two cases of comorbid conditions of Behçet’s disease. The first patient with Behçet’s disease had been examined concurrent development of intestinal tumor. The second one was diagnosed to have chromic myeloleukemia. The malignant transformation of Behçet’s disease patients, both solid and hematological, is rather rare. Further accumulation of relevant date and its analysis will allow to find out the relationship between malignant disease and chemotherapy in Behçet’s disease.
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Alekberova ZC (2013) Behçet’s disease. Scientific and Practical. Rheumatology 1:52–58
Yazici H, Esen F (2008) Mortality in Behcet’s syndrome. Clin Exp Rheumat 26(suppl. 51):S138–S140
Kaklamani VG, Tzonou A, Kaklamanis PG (2005) Behçet’s disease associated with malignancies. Report of two cases and review of the literature. Clin Exp Rheumatol 23(Suppl. 38):S35–S41
Na SY (2013) Morbidity of solid cancer in Behcet’s disease: analysis of 11 cases in a series of 506 patients. Yonsei Med J 54(4):895–901
International Study Group for Behcet’s Disease (1990) Criteria for diagnosis of Behcet’s disease. Lancet 335:1078–1080
Rutter M, Saunders B, Wilkinson K et al (2004) Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology 126:451–459
Jess T, Loftus EV Jr, Velayos FS et al (2006) Risk of intestinal cancer in inflammatory bowel disease: a population-based study from Olmsted County, Minnesota. Gastroenterology 130:1039–1046
Cengiz M, Altundag MK, Zorlu AF et al (2001) Malignancy in Behcet’s disease: a report of 13 cases and a review of the literature. Clin Rheumatol 20:239–244
Yamada M (2011) Colon cancer arising in an ulcer scar due to intestinal Behcet’s disease. Intern Med 50:429–432
Barhoumi A, Hamzaoni A, Hammami S, Manjoub S (2008) Behcet`s disease associated with malignancies. Report of three cases. Clin Exp Rheum 26(suppl.50):S-21
Tassies D, Cervantes F, Feliu E et al (1992) Behcet’s disease with an onset prior to the appearance of chronic myeloid leukemia. Med Clin 99:67–68
Segawa F, Shimizu Y, Saito E, Kinoshita M (1995) Behcet’s disease induced by interferon therapy for chronic myelogenous leukemia. J Rheumatol 22:1183–1184
Budak-Alpdogan T, Demircay Z, Alpdogan O et al (1997) Behcet’s disease in patients with chronic myelogenous leukemia: possible role of interferon-a treatment in the occurrence of Behcet’s symptoms. Ann Hematol 74:45–48
Vaiopoulos G, Terpos E, Viniou N et al (2001) Behcet’s disease in a patient with chronic myelogenous leukemia under hydroxyurea treatment: a case report and review of the literature. Am J Hematol 66:57–58
Budak-Alpdogan T, Demircay Z, Alpdogan O et al (1998) Skin hyperreactivity of Behcet’s patients (pathergy reaction) is also positive in interferon-a treated chronic myeloid leukaemia patients, indicating similarly altered neutrophil functions in both disorders. Br J Rheumatol 37:1148–1151
Vardiman JW, Melo JV, Baccarani M et al (2008) Chronic myelogenous leukaemia, BCR-ABL1 positive. In: Swerdlow SH, Campo E, Harris NL (eds) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. Lyon, IARC Press, pp 32–37
Tada Y, Koarada S, Haruta Y et al (2006) The association of Behçet’s disease with myelodysplastic syndrome in Japan: a review of the literature. Clin Exp Rheumatol 24(Suppl. 42):S115–S119
Kimura S, Kuroda J, Akaogi T et al (2001) Trisomy 8 involved in myelodysplastic syndromes as a risk factor for intestinal ulcers and thrombosis in Behcet’s syndrome. Leuk Lymphoma 42:115–121
Eder L, Rozenbaum M, Boulman N et al (2005) Behcet`s disease, myelodysplastic syndrome trisomy 8, gastroenterological involvement—an association. Clin Exp Rheum 23(suppl 38):S91–S95
Lin YC, Liang TH, Chang HN et al (2008) Behçet disease associated with myelodysplastic syndrome. J Clin Rheumatol 14(3):169–174
Mantzourani M, Chantziara K, Thanopoulou I et al (2009) Coexistence of Behcet`s disease and chronic myelomonocyte leukemia with trisomy 8: a case report and review of the literature. Clin Exp Rheum 27(suppl. 53):S85–S87
Chen Huang-Chi, Chiu Ying-Ming (2012) Large-vessel thrombosis in intestinal Behçet’s disease complicated with myelodysplastic syndrome and trisomy 8. World J Gastroenterol 18(10):1137–1140
Safe T, Ontsuka H, Safo M, et al. Remission of intestinal Behçet’s disease after induction chemotherapy into acute myeloid leukemia M4 inv16. 15th Intern Conference on Behcet’s disease. Abstract book 13–15 July 2012 Yokohama, p 6-1-099 p 88
Lim SH, Hulsey M, Esler WV (2009) Resolution of Behcet’s disease after non-myeloablative allogeneic stem cell transplant for acute myeloid leukaemia. Rheumatology 48:88–89
Tomonari A, Tojo A, Takahashi T et al (2004) Resolution of Behcet’s disease after HLA-mismatched unrelated cord blood transplantation for myelodysplastic syndrome. Ann Hematol 83:464–466
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Alekberova, Z., Gorodetskiy, V., Izmailova, F. et al. Behçet’s disease and comorbidity: internal case reports and literature review. Rheumatol Int 35, 1743–1747 (2015). https://doi.org/10.1007/s00296-015-3232-2
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DOI: https://doi.org/10.1007/s00296-015-3232-2