Rheumatology International

, Volume 34, Issue 10, pp 1361–1367

Effects of 12-week combined exercise therapy on oxidative stress in female fibromyalgia patients


    • Department of Physical Medicine and Rehabilitation, School of MedicineNamik Kemal University
  • Aliye Yıldırım Güzelant
    • Department of Physical Medicine and Rehabilitation, School of MedicineNamik Kemal University
  • Eda Çelik Güzel
    • Department of Family Medicine, School of MedicineNamik Kemal University
  • Savaş Güzel
    • Department of Biochemistry, School of MedicineNamik Kemal University
  • Ali Rıza Kızıler
    • Department of Biophysics, School of MedicineNamik Kemal University
Original Article

DOI: 10.1007/s00296-014-2978-2

Cite this article as:
Sarıfakıoğlu, B., Güzelant, A.Y., Güzel, E.Ç. et al. Rheumatol Int (2014) 34: 1361. doi:10.1007/s00296-014-2978-2


The aims of this study were to investigate the effect of exercise therapy on the oxidative stress in fibromyalgia patients and relationship between oxidative stress and fibromyalgia symptoms. Thirty women diagnosed with fibromyalgia according to the American College of Rheumatology preliminary criteria, and 23 healthy women whose age- and weight-matched women were enrolled the study. Pain intensity with visual analog scale (VAS), the number of tender points, the fibromyalgia impact questionnaire (FIQ), the Beck depression inventory (BDI) were evaluated. The oxidative stress parameters thiobarbituric acid reactive substances, protein carbonyls, and nitric oxide, and antioxidant parameters thiols and catalase were investigated in patients and control group. After, combined aerobic and strengthen exercise regimen was given to fibromyalgia group. Exercise therapy consisted of a warming period of 10 min, aerobic exercises period of 20 min, muscle strengthening exercises for 20 min, and 10 min cooling down period. Therapy was lasting 1 h three times per week over a 12-week period. All parameters were reevaluated after the treatment in the patient group. The oxidative stress parameters levels were significantly higher, and antioxidant parameters were significantly lower in patients with fibromyalgia than in the controls. VAS, FIQ, and BDI scores decreased significantly with exercise therapy. The exercise improved all parameters of oxidative stress and antioxidant parameters. Also, all clinical parameters were improved with exercise. We should focus on oxidative stress in the treatment for fibromyalgia with the main objective of reducing oxidative load.


FibromyalgiaOxidative stressAntioxidant statusExercise

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© Springer-Verlag Berlin Heidelberg 2014